Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	124171
Country	France

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Safety and diagnostic performance of endoscopic ultrasound-guided fine needle biopsy in pancreatic cystic and mixed lesions
Manuscript Source	Invited Manuscript
All Author List	Nada El-Domiaty, Rita Bou-Farah, Valerie Laurent, Christophe Bellanger, Isabelle Boytchev and Antoine Martin
Funding Agency and Grant Number
Corresponding Author	Antoine Martin, Assistant Professor, Department of Gastroenterology and Gastrointestinal Endoscopy, Kremlin-Bicêtre Hospital, Assistance Publique - Hôpitaux de Paris, 78 Rue du Général Leclerc, Le Kremlin-Bicêtre, Paris 94800, France. antoine.martin2@aphp.fr
Key Words	Pancreatic cystic lesion; Pancreatic mixed lesion; Endoscopic ultrasound; Fine needle biopsy; Cyst fluid
Core Tip	Pancreatic cystic and mixed lesions remain diagnostically challenging because conventional imaging and cyst fluid analysis may not reliably differentiate benign from premalignant or malignant lesions. In this retrospective cohort of 60 patients, Endoscopic ultrasound-fine needle biopsy using a 22G needle was feasible, with 100% technical success, 95% specimen adequacy, 85% diagnostic yield, and no procedure-related adverse events identified after medical-record review. Complete concordance with surgical histopathology was observed in the 10 resected patients, but this selected subgroup is not sufficient to estimate overall diagnostic accuracy. These results suggest that endoscopic ultrasound-fine needle biopsy can provide valuable histologic tissue for lesion characterization, particularly in mixed lesions, while prospective comparative studies remain necessary.
Citation	El-Domiaty N, Bou-Farah R, Laurent V, Bellanger C, Boytchev I, Martin A. Safety and diagnostic performance of endoscopic ultrasound-guided fine needle biopsy in pancreatic cystic and mixed lesions. World J Gastrointest Endosc 2026; In press

Received	2026-06-09 01:30
Peer-Review Started	2026-06-09 01:30
First Decision by Editorial Office Director
Return for Revision	2026-07-01 06:06
Revised	2026-07-15 21:08
Publication Fee Transferred
Second Decision by Editor	2026-07-27 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 08:53
Articles in Press	2026-07-27 08:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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