Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	124175
DOI	10.5495/wjcid.124175
Country	Egypt

Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Post-acute COVID-19 gastrointestinal sequelae: Mechanisms of persistent dysbiosis, intestinal barrier dysfunction, and emerging long-COVID phenotypes
Manuscript Source	Unsolicited Manuscript
All Author List	Ahmed Salman
Funding Agency and Grant Number
Corresponding Author	Ahmed Salman, FRACP, FRCP, MRCP, Internal Medicine, Kasr Alainy School of Medicine, 1 Al-Saray Street, Al-Manial, Cairo 3178, Al Qāhirah, Egypt. awea844@gmail.com
Key Words	Long COVID; Gut dysbiosis; Intestinal barrier dysfunction; Short-chain fatty acids; Microbiota-targeted therapy
Core Tip	Long-coronavirus disease gastrointestinal manifestations affect 10%-30% of survivors, but remain overlooked. Persistent dysbiosis-the loss of beneficial bacteria and pathogenic enrichment-drives symptoms through barrier dysfunction, immune dysregulation, and endotoxemia. Dysbiosis has been implicated as a potential contributor to short-chain fatty acid depletion and impaired tryptophan metabolism; however, current human evidence is largely observational, and causality remains unproven. Clinical biomarkers (zonulin, I-FABP, and dysbiotic signatures) enable patient stratification. Microbiota-targeted interventions (probiotics, synbiotics, fecal microbiota transplantation, and postbiotics) offer rational therapeutic approaches. This review establishes dysbiosis as a central therapeutic target and provides an evidence-based framework for its clinical management.
Citation	Salman A. Post-acute COVID-19 gastrointestinal sequelae: Mechanisms of persistent dysbiosis, intestinal barrier dysfunction, and emerging long-COVID phenotypes. World J Clin Infect Dis 2026; In press DOI: https://doi.org/10.5495/wjcid.124175
PDF	124175-in-press.pdf

Received	2026-06-09 03:21
Peer-Review Started	2026-06-09 03:21
First Decision by Editorial Office Director
Return for Revision	2026-06-25 06:08
Revised	2026-07-01 08:41
Publication Fee Transferred
Second Decision by Editor	2026-07-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-14 07:59
Articles in Press	2026-07-14 07:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3176 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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