Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124180
DOI	10.4251/wjgo.124180
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Development and external assessment of a risk prediction model for colorectal adenoma after endoscopic resection
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Bo Xiong, Qin-Xing Cao, Jun-Wen Fu, Wei Deng, Hong-Guang Zhou and Jun Li
Funding Agency and Grant Number	Funding Agency Grant Number the 2026 Chengdu Municipal Medical Research Project 2026229 the 2025 Hospital-level Research Project of the Affiliated Hospital of Chengdu University Y202515
Corresponding Author	Hai-Bo Xiong, MD, Department of Gastrointestinal Surgery, Affiliated Hospital of Chengdu University, No. 82 North Second Section of Second Ring Road, Jinniu District, Chengdu 610081, Sichuan Province, China. 1447594519@qq.com
Key Words	Colorectal adenoma; Risk factor; Prediction model; Risk scoring chart; Intermediate-follow-up external assessment; Surveillance; Endoscopy
Core Tip	This large multicentre study developed a simplified risk prediction model for colorectal adenoma recurrence after endoscopic resection in a Chinese cohort of 5161 patients and assessed it in external cohorts at intermediate follow-up. The 5-item scoring system (age, sex, polyp size, polyp number, and histology) stratified patients into three risk groups in the development cohort, with 3-year recurrence rates of 26.4%, 47.9%, and 62.5% for low-, intermediate-, and high-risk groups, respectively. External assessment in two independent cohorts at intermediate follow-up (13.1-14.1 months) showed low-to-moderate discriminative performance (area under the receiver operating characteristic curve: 0.661 and 0.639). Formal external validation for the 3-year endpoint was not feasible due to limited long-term follow-up in external cohorts. This tool enables individualized post-polypectomy surveillance recommendations and fills an important gap in Chinese clinical practice.
Citation	Xiong HB, Cao QX, Fu JW, Deng W, Zhou HG, Li J. Development and external assessment of a risk prediction model for colorectal adenoma after endoscopic resection. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124180
PDF	124180-in-press.pdf

Received	2026-06-09 08:36
Peer-Review Started	2026-06-09 08:39
First Decision by Editorial Office Director
Return for Revision	2026-08-04 10:46
Revised	2026-08-15 09:36
Publication Fee Transferred	2026-09-12 08:50
Second Decision by Editor	2026-11-02 02:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:23
Articles in Press	2026-11-04 10:23
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com