Publication Name	World Journal of Gastroenterology
Manuscript ID	124209
DOI	10.3748/wjg.124209
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Diagnostic performance of multiple peripheral blood inflammatory markers for hepatocellular carcinoma and development of a diagnostic nomogram
Manuscript Source	Unsolicited Manuscript
All Author List	Qin-Peng Li, Li-Li Zhan, Xin-Yu Lin and Yan-Rong Peng
Funding Agency and Grant Number	Funding Agency Grant Number Sanming Project of Medicine in Shenzhen No. SZSM202311002 Special Foundation for the Development of Strategic Emerging Industries of Shenzhen Municipality No. F-2023-Z99-509269
Corresponding Author	Li-Li Zhan, Principal Investigator, Clinical Laboratory Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 113 Baohe Road, Longgang District, Shenzhen 518116, Guangdong Province, China. zhanlily@163.com
Key Words	Hepatocellular carcinoma; Inflammatory markers; Nomogram; Prognostic nutritional index; Lymphocyte-to-monocyte ratio; Diagnosis
Core Tip	This study systematically evaluated eight peripheral blood inflammatory markers for the auxiliary diagnosis of hepatocellular carcinoma and developed a nomogram. Among all markers, the prognostic nutritional index (PNI) and lymphocyte-to-monocyte ratio (LMR) showed superior diagnostic performance compared with alpha-fetoprotein. A nomogram incorporating PNI, LMR, and neutrophil-to-platelet ratio demonstrated good discrimination, calibration, and clinical utility. These readily available and cost-effective biomarkers may serve as valuable adjuncts to current diagnostic strategies.
Citation	Li QP, Zhan LL, Lin XY, Peng YR. Diagnostic performance of multiple peripheral blood inflammatory markers for hepatocellular carcinoma and development of a diagnostic nomogram. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.124209
PDF	124209-in-press.pdf

Received	2026-06-10 08:53
Peer-Review Started	2026-06-10 08:53
First Decision by Editorial Office Director
Return for Revision	2026-06-17 06:34
Revised	2026-07-01 05:04
Publication Fee Transferred	2026-07-15 02:25
Second Decision by Editor	2026-08-05 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-05 10:51
Articles in Press	2026-08-05 10:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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