Publication Name	World Journal of Hepatology
Manuscript ID	124224
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Metabolic dysfunction-associated steatotic liver disease and the consequence of extra-hepatic malignancy
Manuscript Source	Invited Manuscript
All Author List	Benjamin Blaske, Michael Ward and Ragesh Babu Thandassery
Funding Agency and Grant Number
Corresponding Author	Ragesh Babu Thandassery, Department of Internal Medicine, Division of Gastronterology, University of Arkansas For Medical Sciences, 4300 W 7th St, Little Rock, AR 72205, United States. doc.ragesh@gmail.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Extra-hepatic malignancy; Colorectal cancer; Pancreatic cancer; Breast cancer; Insulin resistance; Obesity; Cancer surveillance; Gut microbiome; Inflammation
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) confers increased risk of extra-hepatic malignancies spanning multiple organ systems, beyond its well-recognized association with hepatocellular carcinoma. Shared oncogenic pathways which include insulin resistance, chronic systemic inflammation, lipotoxicity, and gut dysbiosis, link MASLD to both gastrointestinal (GI) cancers (colorectal, pancreatic, esophagogastric, biliary) and non-GI cancers (breast, gynecologic, thyroid, urinary, lung). Globally, the burden and prevalence of MASLD is rising, with young-onset disease and advanced fibrosis as key risk amplifiers. Dedicated cancer surveillance protocols for MASLD populations are urgently needed.
Citation	Blaske B, Ward M, Thandassery RB. Metabolic dysfunction-associated steatotic liver disease and the consequence of extra-hepatic malignancy. World J Hepatol 2026; In press

Received	2026-06-09 01:29
Peer-Review Started	2026-06-09 01:30
First Decision by Editorial Office Director
Return for Revision	2026-06-16 06:53
Revised	2026-07-09 21:11
Publication Fee Transferred
Second Decision by Editor	2026-07-23 07:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 09:06
Articles in Press	2026-07-27 09:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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