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Articles in Press
10/8/2026 9:07:22 AM | Browse: 3 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
APOB mutations in familial hypobetalipoproteinemia presenting with cirrhosis and hepatocellular carcinoma in a Chinese male: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Xue Yuan, Lei Sun and Song Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Beijing |
No. 7262066 |
| the Capital Medical University Scientific Research Cultivation Fund for Natural Category |
No. PYZ25161 |
| Qinghai Province Kunlun Talent: Top-level Innovation and Entrepreneurship Talent |
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| Corresponding Author |
Song Yang, MD, PhD, Professor, Department of Infectious Diseases, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Beijing 100029, China. sduyangsong@163.com |
| Key Words |
Familial hypobetalipoproteinemia; Hepatocellular carcinoma; APOB mutation; Cirrhosis; Metabolism-associated steatotic liver disease; Case report |
| Core Tip |
Three APOB variants were identified in a Chinese patient with familial hypobetalipoproteinemia (FHBL)-related cirrhosis who progressed to subsequent hepatocellular carcinoma. FHBL does not have an invariably benign clinical course as the coexistence of compoun heterozygous mutations and metabolic comorbidities, particularly type 2 diabetes, markedly increases the risk of liver disease progression. For patients with cryptogenic cirrhosis and unexpectedly low low-density lipoprotein cholesterol or apolipoprotein B levels, genetic testing is a definitive tool for clarifying the underlying pathogenesis. Regular hepatocellular carcinoma imaging is strongly recommended in the long-term follow-up of FHBL patients with advanced hepatic fibrosis or concurrent metabolic risk factors. |
| Citation |
Yuan XX, Sun L, Yang S. APOB mutations in familial hypobetalipoproteinemia presenting with cirrhosis and hepatocellular carcinoma in a Chinese male: A case report. World J Gastroenterol 2026; In press
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Received |
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2026-06-25 08:29 |
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Peer-Review Started |
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2026-06-25 08:29 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-03 03:40 |
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Revised |
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2026-08-12 16:06 |
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Publication Fee Transferred |
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2026-08-19 12:51 |
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Second Decision by Editor |
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2026-10-08 07:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-08 09:07 |
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Articles in Press |
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2026-10-08 09:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
