Publication Name	World Journal of Psychiatry
Manuscript ID	124324
DOI	10.5498/wjp.124324
Country	China

Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Interoceptive aberrations in major depressive disorder: Neural mechanisms, clinical correlates, and targeted interventions
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Deng, Ya-Qing Wang, Hong-Liang Zhou and Zhen-He Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Wuxi Municipal Health Commission Major Project Z202107 Wuxi Taihu Talent Project WXTTP 2021
Corresponding Author	Zhen-He Zhou, Chief Physician, MD, PhD, Professor, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Wuxi 214151, Jiangsu Province, China. zhouzh@jiangnan.edu.cn
Key Words	Interoception; Major depressive disorder; Active inference; Brain-body regulation; Somatic symptoms; Neural networks; Therapeutic interventions
Core Tip	This narrative review reframes the apparently inconsistent interoceptive findings in major depressive disorder (MDD) as a multidimensional pattern, with part of the apparent heterogeneity across studies related to measurement choice and illness stage. By comparing major assessment approaches and integrating behavioral, neurobiological, and clinical evidence, we identify where findings across interoceptive domains converge and diverge, with active inference serving as a heuristic perspective for interpreting selected links across levels of analysis. This synthesis points toward future stage-sensitive, multimodal assessment and more mechanism-informed intervention research in MDD.
Citation	Deng H, Wang YQ, Zhou HL, Zhou ZH. Interoceptive aberrations in major depressive disorder: neural mechanisms, clinical correlates, and targeted interventions. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.124324
PDF	124324-in-press.pdf

Received	2026-06-12 08:49
Peer-Review Started	2026-06-12 08:50
First Decision by Editorial Office Director
Return for Revision	2026-07-27 02:27
Revised	2026-08-09 15:42
Publication Fee Transferred	2026-08-26 01:40
Second Decision by Editor	2026-09-15 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-15 09:31
Articles in Press	2026-09-15 09:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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