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Articles in Press
11/5/2026 7:20:35 AM | Browse: 3 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Lymphangiogenesis-related prognostic gene signature for hepatocellular carcinoma identified by integrative multi-omics and causal inference
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jiao Li, Cui Deng, Si-Min Zhang, Chi Ma, Yan-Fang Wei, Zheng-Deng Li, Xue Su, Juan Yang and Sheng Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| General Program of Joint Special Fund for Basic Research of Local Universities (Yunnan Province) |
202301BA070001-029, 202301BA070001-044 |
| Project for Reserve Talents of Young and Middle-aged Academic and Technical Leaders under the Special Program for the Selection of High-level Scientific and Technological Talents and Innovation Teams of Yunnan Province |
202405AC350067 |
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| Corresponding Author |
Sheng Zheng, Full Professor, Department of Gastroenterology, The Third People’s Hospital of Yunnan Province, No. 292 Beijing Road, Guandu District, Kunming 650011, Yunnan Province, China. zheng_sheng523@sina.com |
| Key Words |
Hepatocellular carcinoma; Lymphangiogenesis; Mendelian randomization analysis; Prognostic genes; Single-cell analysis |
| Core Tip |
Hepatocellular carcinoma carries a poor prognosis, and the clinical value of lymphangiogenesis-related genes remains unclear. Integrating multi-omics, Mendelian randomization, and single-cell sequencing, this study identified COL15A1, LOXL2, and PLXDC1 as prognostic genes and constructed a robust risk stratification model. Multidimensional analyses revealed their roles in immune remodeling, metabolic alteration, and drug sensitivity, providing novel biomarkers and causal evidence for individualized prognosis assessment in hepatocellular carcinoma. |
| Citation |
Li J, Deng C, Zhang SM, Ma C, Wei YF, Li ZD, Su X, Yang J, Zheng S. Lymphangiogenesis-related prognostic gene signature for hepatocellular carcinoma identified by integrative multi-omics and causal inference. World J Hepatol 2026; In press
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| PDF |
124343-in-press.pdf
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Received |
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2026-06-12 07:35 |
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Peer-Review Started |
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2026-06-12 07:36 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-09 06:04 |
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Revised |
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2026-07-22 12:55 |
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Publication Fee Transferred |
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2026-08-14 10:29 |
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Second Decision by Editor |
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2026-11-05 03:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-05 07:20 |
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Articles in Press |
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2026-11-05 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
