Publication Name	World Journal of Gastroenterology
Manuscript ID	124353
DOI	10.3748/wjg.124353
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Pretreatment routine-data prediction of mucosal healing after infliximab in Crohn’s disease: A multicenter retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	An-Feng Chen, Sheng-Nan Zhu, Zi-Chun Wang, Ming-Hui Yu, You Lu, Rui-Dong Chen and Qi-Ming Fu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 62372318 Pre-research Fund Project of the Second Affiliated Hospital of Soochow University SDFEYJC2435
Corresponding Author	Qi-Ming Fu, Associate Professor, Deputy Director, PhD, School of Electronic and Information Engineering, Suzhou University of Science and Technology, No. 99 Xuefu Road, Huqiu District, Suzhou 215009, Jiangsu Province, China. fqm_1@126.com
Key Words	Crohn’s disease; Infliximab; Mucosal healing; Machine learning; Nutritional-Inflammatory Index; Routine clinical data
Core Tip	Primary non-response to infliximab (IFX) remains difficult to anticipate before treatment in Crohn’s disease. This multicenter study developed and externally validated an interpretable routine-data model to identify biologic-naïve patients who are likely to achieve week-52 mucosal healing after IFX. Using only baseline clinical and laboratory variables, the model identified a high predicted-response subgroup with a 92.1% mucosal healing rate. These findings suggest that the model may support more individualized pretreatment decisions by recognizing patients highly likely to benefit from IFX.
Citation	Chen AF, Zhu SN, Wang ZC, Yu MH, Lu Y, Chen RD, Fu QM. Pretreatment routine-data prediction of mucosal healing after infliximab in Crohn’s disease: A multicenter retrospective study. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.124353
PDF	124353-in-press.pdf

Received	2026-06-12 07:35
Peer-Review Started	2026-06-12 07:36
First Decision by Editorial Office Director
Return for Revision	2026-07-13 04:04
Revised	2026-07-22 19:44
Publication Fee Transferred	2026-08-07 09:25
Second Decision by Editor	2026-09-11 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-11 09:21
Articles in Press	2026-09-11 09:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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