Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	124378
DOI	10.4240/wjgs.124378
Country	China

Category	Transplantation
Manuscript Type	Minireviews
Article Title	Mechanisms, clinical translation, and future perspectives of liver-mediated immunoprotection in combined organ transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Zheng-Wei Zhao, Yu-Guo Chen and Guang-Yi Wang
Funding Agency and Grant Number
Corresponding Author	Guang-Yi Wang, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. guangyi@jlu.edu.cn
Key Words	Liver transplantation; Intestinal transplantation; Multivisceral transplantation; Immune tolerance; Immunoprotection; Combined transplantation
Core Tip	This review highlights the immunoprotective mechanisms of the liver in combined intestinal and multivisceral transplantation, including liver sinusoidal endothelial cell-mediated antigen presentation, regulatory T cell enrichment, clonal deletion, and donor-specific antibody clearance. Concurrent liver inclusion reduces rejection rates but increases risks of graft-vs-host disease and infection. Normothermic machine perfusion and regulatory T-cell therapy represent promising strategies for optimizing immunomodulation.
Citation	Zhao ZW, Chen YG, Wang GY. Mechanisms, clinical translation, and future perspectives of liver-mediated immunoprotection in combined organ transplantation. World J Gastrointest Surg 2026; In press DOI: https://doi.org/10.4240/wjgs.124378
PDF	124378-in-press.pdf

Received	2026-06-12 10:50
Peer-Review Started	2026-06-12 10:52
First Decision by Editorial Office Director
Return for Revision	2026-07-02 03:37
Revised	2026-07-06 12:09
Publication Fee Transferred	2026-07-08 09:10
Second Decision by Editor	2026-08-31 03:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-31 08:44
Articles in Press	2026-08-31 08:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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