Publication Name	World Journal of Gastroenterology
Manuscript ID	124393
DOI	10.3748/wjg.124393
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Significant response to tislelizumab plus bevacizumab in a patient with microsatellite instability-high colon cancer: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Fei Chen, Chi Huang, Zhi-Jian Chen and Zhi-Hui Wang
Funding Agency and Grant Number
Corresponding Author	Zhi-Hui Wang, MD, PhD, Department of Gastrointestinal Surgery, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang’an District, Wuhan 430000, Hubei Province, China. wangzhihui@tmu.edu.cn
Key Words	Colon neoplasms; Immune checkpoint inhibitors; Angiogenesis inhibitors; Microsatellite instability; KRAS mutation; Three primary cancers; Case report
Core Tip	This case report describes a rare patient with triple primary malignancies, including microsatellite instability-high/KRAS-mutated advanced colorectal cancer, with a history of clinically cured gastric and ovarian cancers, who achieved marked radiological remission following conversion therapy with tislelizumab combined with bevacizumab. The target-lesion longest diameter decreased by 72.3%, meeting Response Evaluation Criteria in Solid Tumors 1.1 criteria for a confirmed partial response. Germline testing identified a pathogenic MSH2 variant, establishing Lynch syndrome. This observation highlights the potential of combining programmed death-1 inhibitors with anti-angiogenic targeted agents in selected patients with advanced microsatellite instability-high colorectal cancer and warrants further investigation.
Citation	Chen YF, Huang C, Chen ZJ, Wang ZH. Significant response to tislelizumab plus bevacizumab in a patient with microsatellite instability-high colon cancer: A case report and review of literature. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.124393
PDF	124393-in-press.pdf

Received	2026-06-15 07:26
Peer-Review Started	2026-06-15 07:27
First Decision by Editorial Office Director
Return for Revision	2026-07-16 05:31
Revised	2026-07-29 16:45
Publication Fee Transferred	2026-08-25 05:02
Second Decision by Editor	2026-09-14 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-15 09:32
Articles in Press	2026-09-15 09:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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