Publication Name	World Journal of Clinical Oncology
Manuscript ID	124416
DOI	10.5306/wjco.124416
Country	China

Category	Oncology
Manuscript Type	Observational Study
Article Title	Efficacy of two programmed cell death 1 combination regimens in recurrent and/or metastatic head and neck carcinoma: A real-world retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Xin Wang, Tian-Xiao Wang, Yun-Tao Song, Guo-Hui Xu, Ya-Bing Zhang and Bin Zhang
Funding Agency and Grant Number
Corresponding Author	Bin Zhang, Department of Head and Neck Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. docbinzhang@hotmail.com
Key Words	Head and neck squamous cell carcinoma; Programmed cell death 1 inhibitor; Cetuximab; Anlotinib; Immuno-targeted therapy
Core Tip	Programmed cell death 1 (PD-1) inhibitors combined with cetuximab or anlotinib exhibit distinct therapeutic profiles in recurrent and/or metastatic head and neck squamous cell carcinoma. In this real-world cohort study, PD-1 inhibitor plus cetuximab was associated with significantly prolonged overall survival, whereas PD-1 inhibitor plus anlotinib showed favorable tumor response and disease control. These distinct efficacy profiles may help inform individualized treatment selection for PD-1-based immunotherapy-targeted therapy combinations.
Citation	Wang JX, Wang TX, Song YT, Xu GH, Zhang YB, Zhang B. Efficacy of two programmed cell death 1 combination regimens in recurrent and/or metastatic head and neck carcinoma: A real-world retrospective study. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.124416
PDF	124416-in-press.pdf

Received	2026-06-15 08:34
Peer-Review Started	2026-06-15 08:34
First Decision by Editorial Office Director
Return for Revision	2026-07-24 06:38
Revised	2026-08-05 23:57
Publication Fee Transferred	2026-09-01 09:14
Second Decision by Editor	2026-09-22 03:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-22 09:54
Articles in Press	2026-09-22 09:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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