Publication Name	World Journal of Gastroenterology
Manuscript ID	124419
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Fexuprazan vs esomeprazole for endoscopic submucosal dissection-induced gastric ulcer healing: A double-blind randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Hye Kyung Hyun, Jin Ho Hwang, Nak-Hoon Son, So Hyeon Gwon, Da Hyun Jung and Cheal Wung Huh
Funding Agency and Grant Number
Corresponding Author	Cheal Wung Huh, Associate Professor, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Dongbaekjukjeon-daero Road, Giheung-gu District, Yongin 16995, Gyeonggi-do, South Korea. huhcw@yuhs.ac
Key Words	Fexuprazan; Potassium-competitive acid blocker; Esomeprazole; Endoscopic submucosal dissection; Gastric ulcer; Randomized controlled trial
Core Tip	This double-blind, double-dummy randomized controlled trial compared the potassium-competitive acid blocker fexuprazan with the proton pump inhibitor esomeprazole for the healing of artificial gastric ulcers after endoscopic submucosal dissection. Ulcer healing was assessed endoscopically at 4 weeks and 8 weeks. Fexuprazan achieved a significantly higher complete healing rate at 8 weeks in the pre-specified PP analysis (90.2% vs 75.0%) and greater ulcer shrinkage at both time points, although the difference was not significant in the modified intention-to-treat population. In an exploratory analysis, the model-estimated healing time was shorter with fexuprazan, particularly for large baseline ulcers (≥ 800 mm2). The safety profile was comparable between groups.
Citation	Hyun HK, Hwang JH, Son NH, Gwon SH, Jung DH, Huh CW. Fexuprazan vs esomeprazole for endoscopic submucosal dissection-induced gastric ulcer healing: A double-blind randomized controlled trial. World J Gastroenterol 2026; In press

Received	2026-06-16 03:23
Peer-Review Started	2026-06-16 03:24
First Decision by Editorial Office Director
Return for Revision	2026-08-11 09:16
Revised	2026-08-24 12:01
Publication Fee Transferred	2026-10-01 04:50
Second Decision by Editor	2026-10-23 02:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-23 09:07
Articles in Press	2026-10-23 09:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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