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Articles in Press
9/21/2026 9:40:33 AM | Browse: 1 | Download: 0
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Perineural invasion in pancreatic ductal adenocarcinoma: Molecular mechanisms and clinical significance
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rong Hu, Hong-Chen Zhang and Xiao-Feng Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Construction Fund of Key Medical Disciplines of Hangzhou |
No. 2025HZGF05 |
| Zhejiang Provincial Key Research and Development Program |
No. 2024C03048 |
| Zhejiang Provincial Key Discipline of Integrated Traditional Chinese and Western Medicine (Digestive Diseases) |
No. 2024-XK-61 |
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| Corresponding Author |
Xiao-Feng Zhang, Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University; Hangzhou Institute of Digestive Diseases; Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, No. 261, Huansha Road, Hangzhou 310006, Zhejiang Province, China. zhangxiaofeng@hospital.westlake.edu.cn |
| Key Words |
Pancreatic ductal adenocarcinoma; Perineural invasion; Tumor microenvironment; Neurotrophic factors; Spatial omics; Targeted therapy |
| Core Tip |
This article organizes perineural invasion in pancreatic ductal adenocarcinoma around a spatially organized neural-invasion niche, integrating neural-immune-stromal-metabolic crosstalk while preserving differences in evidence strength. Its key contribution is to connect this niche framework with a dual pain model that distinguishes mechanical injury and compression from chemical and neuroimmune sensitization. Clinical implications remain evidence-bounded: Spatial omics is research-stage, and diagnostic or therapeutic translation requires prospective validation with perineural invasion-specific endpoints. |
| Citation |
Hu R, Zhang HC, Zhang XF. Perineural invasion in pancreatic ductal adenocarcinoma: Molecular mechanisms and clinical significance. World J Gastrointest Oncol 2026; In press
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Received |
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2026-06-15 09:09 |
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Peer-Review Started |
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2026-06-15 09:10 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-29 02:28 |
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Revised |
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2026-08-12 02:15 |
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Publication Fee Transferred |
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2026-08-20 14:27 |
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Second Decision by Editor |
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2026-09-21 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-21 09:40 |
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Articles in Press |
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2026-09-21 09:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
