Publication Name	World Journal of Hepatology
Manuscript ID	124436
Country	Slovakia

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Small dense low-density lipoprotein in primary biliary cholangitis: Independent association with metabolic syndrome
Manuscript Source	Invited Manuscript
All Author List	Tomas Koky, Sylvia Drazilova, Martin Janicko, Martin Harhovsky, Beata Hubkova, Ivana Tothova, Miroslava Rabajdova, Maria Marekova and Peter Jarcuska
Funding Agency and Grant Number
Corresponding Author	Sylvia Drazilova, Associate Professor, MD, PhD, 2nd Department of Internal Medicine, PJ Safarik University, Faculty of Medicine and L Pasteur University Hospital, Trieda SNP 1, Kosice 04011, Slovakia. sylvia.drazilova@upjs.sk
Key Words	Primary biliary cholangitis; Small dense low-density lipoprotein; Metabolic dysfunction; Lipoprotein subfractions; Atherogenic dyslipidemia
Core Tip	Hypercholesterolemia in primary biliary cholangitis (PBC) is largely driven by cholestasis and lipoprotein X, making conventional lipid parameters difficult to interpret. In this study, small dense low-density lipoprotein (LDL) was independently associated with metabolic syndrome but not with liver fibrosis, cholestatic activity, metabolic dysfunction-associated steatotic liver disease, or biochemical response. These findings suggest that small dense LDL reflects superimposed metabolic dysfunction rather than intrinsic cholestatic liver disease and may help identify a metabolically driven atherogenic phenotype in contemporary PBC cohorts.
Citation	Koky T, Drazilova S, Janicko M, Harhovsky M, Hubkova B, Tothova I, Rabajdova M, Marekova M, Jarcuska P. Small dense low-density lipoprotein in primary biliary cholangitis: Independent association with metabolic syndrome. World J Hepatol 2026; In press

Received	2026-06-15 02:11
Peer-Review Started	2026-06-15 02:11
First Decision by Editorial Office Director
Return for Revision	2026-07-03 09:22
Revised	2026-07-13 12:10
Publication Fee Transferred
Second Decision by Editor	2026-07-24 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 07:48
Articles in Press	2026-07-27 07:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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