Publication Name	World Journal of Hepatology
Manuscript ID	124439
DOI	10.4254/wjh.124439
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Association between fibrosis-4 index and all-cause mortality by hepatic steatosis category in United States adults: A retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Lu, Zhao-Yun Liu, Chao Guo and Qing-Quan Gong
Funding Agency and Grant Number	Funding Agency Grant Number Fujian University of Traditional Chinese Medicine No. XB2024208
Corresponding Author	Qing-Quan Gong, Adjunct Associate Professor, MD, Gastroenterology, Mindong Hospital Affiliated to Fujian Medical University, 89 Heshan Road, Ningde 355000, Fujian Province, China. gqq96398@sina.com
Key Words	Hepatic steatosis index; Fibrosis-4 index; All-cause mortality; National Health and Nutrition Examination Survey; Risk assessment; Survival analysis
Core Tip	Elevated fibrosis-4 index (FIB-4) was associated with higher all-cause mortality within the hepatic steatosis index (HSI) 30-36 and > 36 categories, but the overall interaction was not statistically significant. The observed gains in predictive performance were statistically detectable but small and do not establish clinical utility. Because HSI and FIB-4 share aminotransferase components and FIB-4 is influenced by age and platelet count, elevated FIB-4 should be interpreted as a composite risk marker rather than direct evidence of advanced liver fibrosis.
Citation	Lu J, Liu ZY, Guo C, Gong QQ. Association between fibrosis-4 index and all-cause mortality by hepatic steatosis category in United States adults: A retrospective cohort study. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124439
PDF	124439-in-press.pdf

Received	2026-06-15 09:09
Peer-Review Started	2026-06-15 09:10
First Decision by Editorial Office Director
Return for Revision	2026-08-06 14:43
Revised	2026-08-25 18:09
Publication Fee Transferred	2026-09-24 09:17
Second Decision by Editor	2026-11-05 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 07:31
Articles in Press	2026-11-05 07:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com