Publication Name	World Journal of Hepatology
Manuscript ID	124474
Country	Thailand

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Age-male-albumin-bilirubin-platelet score stratifies hepatocellular carcinoma risk after sustained virological response in hepatitis C-related compensated advanced chronic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Sirajuk Khongviwatsathien and Tawesak Tanwandee
Funding Agency and Grant Number
Corresponding Author	Tawesak Tanwandee, MD, Professor, Division of Gastroenterology, Department of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road Bangkoknoi, Bangkok 10700, Thailand. tawesak@gmail.com
Key Words	Hepatitis C virus; Compensated advanced chronic liver disease; Direct-acting antiviral therapy; Sustained virological response; Hepatocellular carcinoma; Age-male-albumin-bilirubin-platelet score; Risk stratification; Surveillance de-escalation
Core Tip	This retrospective cohort study evaluated the age-male-albumin-bilirubin-platelet (aMAP) score for predicting hepatocellular carcinoma (HCC) risk after sustained virological response in patients with hepatitis C virus-related compensated advanced chronic liver disease. Among 571 patients followed for a median of 4.59 years, 78 developed HCC. The aMAP score outperformed other noninvasive scoring systems, and an exploratory threshold of < 55 identified 18.6% of patients with no observed HCC events. These findings suggest that the aMAP score may support individualized surveillance intensity; however, the threshold requires external validation before routine clinical implementation.
Citation	Khongviwatsathien S, Tanwandee T. Age-male-albumin-bilirubin-platelet score stratifies hepatocellular carcinoma risk after sustained virological response in hepatitis C-related compensated advanced chronic liver disease. World J Hepatol 2026; In press

Received	2026-06-17 03:36
Peer-Review Started	2026-06-17 03:37
First Decision by Editorial Office Director
Return for Revision	2026-06-29 03:51
Revised	2026-07-09 16:34
Publication Fee Transferred	2026-07-14 14:50
Second Decision by Editor	2026-07-23 07:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 07:30
Articles in Press	2026-07-27 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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