Publication Name	World Journal of Gastroenterology
Manuscript ID	124537
DOI	10.3748/wjg.124537
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Serum pepsinogen combined with computed tomography imaging for diagnosing recurrence of gastric cancer after total gastrectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Jiu-Ru Zhang, Xue-Wen Xu, Jia-Meng Liu, Zhi-Hong Zhu and Chao-Ming Mao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81370889 the Key Research and Development Plan of Zhenjiang City SH2022046 and JDYY2023006
Corresponding Author	Chao-Ming Mao, Academic Fellow, PhD, Professor, Department of Nuclear Medicine, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Jingkou District, Zhenjiang 212000, Jiangsu Province, China. jq1001@ujs.edu.cn
Key Words	Gastric cancer; Total gastrectomy; Recurrence; Pepsinogen; Multimodal diagnosis; Tumor heterogeneity
Core Tip	This study evaluated the combined diagnostic performance of serum pepsinogen (PG) and computed tomography (CT) imaging for detecting recurrence after total gastrectomy. We found that serum PG and CT imaging play complementary roles, with PG providing early functional warning by reflecting secretory tumor burden and CT imaging offering anatomical confirmation. Importantly, PG expression varied substantially by histological differentiation, and this heterogeneity directly influenced the diagnostic sensitivity of serum PG. These findings support a histology-stratified, PG-centered surveillance strategy that integrates functional and morphological information for personalized postoperative follow-up.
Citation	Zhang JR, Xu XW, Liu JM, Zhu ZH, Mao CM. Serum pepsinogen combined with computed tomography imaging for diagnosing recurrence of gastric cancer after total gastrectomy. World J Gastroenterol 2026; In press DOI: https://doi.org/10.3748/wjg.124537
PDF	124537-in-press.pdf

Received	2026-06-18 08:11
Peer-Review Started	2026-06-18 08:11
First Decision by Editorial Office Director
Return for Revision	2026-07-15 08:13
Revised	2026-07-22 03:52
Publication Fee Transferred	2026-07-24 03:59
Second Decision by Editor	2026-07-29 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-29 10:05
Articles in Press	2026-07-29 10:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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