Publication Name	World Journal of Stem Cells
Manuscript ID	124540
DOI	10.4252/wjsc.124540
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ying Yang, Jin-Long Zhong and Jia-Yuan Liu
Funding Agency and Grant Number	Funding Agency Grant Number 2024 Jinshan District Health Special Research Project - General Program JSKJ-KTMS-2024-02
Corresponding Author	Jia-Yuan Liu, Chief Physician, Deputy Director, Department of Thoracic Surgery, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai 201508, China. ljyuan1985@163.com
Key Words	Lung cancer; MED12 mutation; Stemness; CD8+ T; Notch signaling
Core Tip	Mediator complex subunit 12 mutation in lung cancer cells activates Notch signaling, which concurrently promotes cancer stemness - characterized by enhanced sphere formation and increased ALDH1+ cells - and induces immune evasion via upregulation of surface programmed death ligand-1 on tumor cells. This leads to impaired CD8+ T cell chemotaxis, reduced release of effector molecules (interferon-γ, tumor necrosis factor-α, perforin, granzyme-B), and increased programmed cell death 1 expression. Notch inhibitor DAPT reverses these pro-tumor effects.
Citation	Yang Y, Zhong JL, Liu JY. MED12 mutation activates Notch signaling to enhance cancer stemness and suppress CD8+ T cell cytotoxicity in lung cancer. World J Stem Cells 2026; In press DOI: https://doi.org/10.4252/wjsc.124540
PDF	124540-in-press.pdf

Received	2026-06-22 07:11
Peer-Review Started	2026-06-22 07:11
First Decision by Editorial Office Director
Return for Revision	2026-07-09 08:55
Revised	2026-07-18 14:18
Publication Fee Transferred	2026-07-29 01:52
Second Decision by Editor	2026-09-04 06:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-18 10:32
Articles in Press	2026-09-18 10:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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