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Articles in Press
11/4/2026 10:24:17 AM | Browse: 2 | Download: 0
| Category |
Pediatrics |
| Manuscript Type |
Basic Study |
| Article Title |
Endogenous peptide PDLMNA alleviates enteric neural crest cell migration defects via interaction with ALKBH5 and disruption of the LMNA-ALKBH5 complex
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Tao Zhang, Cheng-Long Wang, Zheng-Ke Zhi, Yuan-Xiang Qiu, Zi-Chuan Gao, Ming-Jie Huang, Wei-Bing Tang and Hong-Xing Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
82270540 |
| High-Level Hospital Science and Technology Innovation Support Program Project, Children’s Hospital of Nanjing Medical University |
KJCXQ2024017 |
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| Corresponding Author |
Hong-Xing Li, Associate Professor, MD, PhD, Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing 210008, Jiangsu Province, China. hx8817@njmu.edu.cn |
| Key Words |
ALKBH5; Cytoskeleton; Endogenous peptide; Enteric neural crest cells; Enteric nervous system; Hirschsprung’s disease; LMNA; PDLMNA |
| Core Tip |
Abnormal migration of enteric neural crest cells is a major cause of intestinal developmental abnormalities. This study characterized PDLMNA, an endogenous peptide that binds to α-ketoglutarate-dependent demethylase 5 (ALKBH5) and disrupts the interaction between ALKBH5 and Lamin A/C. PDLMNA effectively restores impaired enteric neural crest cells migration by modulating the LMNA-ALKBH5 complex, revealing a novel peptide-mediated molecular mechanism involved in enteric nervous system development. |
| Citation |
Zhang XT, Wang CL, Zhi ZK, Qiu YX, Gao ZC, Huang MJ, Tang WB, Li HX. Endogenous peptide PDLMNA alleviates enteric neural crest cell migration defects via interaction with ALKBH5 and disruption of the LMNA-ALKBH5 complex. World J Gastroenterol 2026; In press
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| PDF |
124568-in-press.pdf
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Received |
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2026-06-22 12:04 |
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Peer-Review Started |
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2026-06-22 12:04 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-04 01:53 |
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Revised |
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2026-08-17 19:47 |
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Publication Fee Transferred |
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2026-09-19 05:41 |
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Second Decision by Editor |
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2026-11-02 02:19 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-04 10:24 |
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Articles in Press |
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2026-11-04 10:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
