| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical validity and impact of endoscopic atrophic staging for autoimmune gastritis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuichi Terao, Yasuhiko Maruyama, Maki Ayaki, Kouji Ikegami, Shigemi Nakajima, Shoko Ono, Takahisa Furuta, Maiko Kishino, Mototsugu Kato, Ayaka Takasu, Johji Shunto, Rika Aoki, Kengo Tokunaga, Hiroshi Kishikawa, Kazuhiko Inoue, Tohru Kotera, Koichi Okamoto, Shuhei Unno, Shinji Nasu, Chihiro Sumida, Shiho Suzuki, Koichi Kurahara, Hiroshi Kawachi, Ryoji Kushima, Hidenobu Watanabe, Takumi Imai and Ken Haruma |
| Funding Agency and Grant Number |
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| Corresponding Author |
Shuichi Terao, Director, MD, Internal Medicine, Kakogawa Central City Hospital, 439, Honmachi, Kakogawa cho, Kakogawa 675-8611, Hyogo, Japan. stshiratodai2@gmail.com |
| Key Words |
Atrophy; Autoimmune gastritis; Classification; Endoscopy; Remnant oxyntic mucosa |
| Core Tip |
Autoimmune gastritis (AIG) is a progressive disease with increasing clinical consequences as gastric atrophy advances, yet no validated endoscopic staging system currently exists. We developed and validated the AIG atrophic staging (AIG-AS) classification based on the extent of remnant oxyntic mucosa. AIG-AS closely reflected both biological disease progression and clinical impact, showing significant associations with parietal cell antibody titers, gastrin levels, pepsinogen (PG) 1 levels, the PG 1/2 ratio, and anemia risk. These findings support the clinical validity of AIG-AS as the first endoscopic staging system for AIG to be validated against biological and clinical disease progression. |
| Citation |
Terao S, Maruyama Y, Ayaki M, Ikegami K, Nakajima S, Ono S, Furuta T, Kishino M, Kato M, Takasu A, Shunto J, Aoki R, Tokunaga K, Kishikawa H, Inoue K, Kotera T, Okamoto K, Unno S, Nasu S, Sumida C, Suzuki S, Kurahara K, Kawachi H, Kushima R, Watanabe H, Imai T, Haruma K. Clinical validity and impact of endoscopic atrophic staging for autoimmune gastritis. World J Gastroenterol 2026; In press
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