Publication Name	World Journal of Psychiatry
Manuscript ID	124586
Country	China

Category	Psychology, Biological
Manuscript Type	Observational Study
Article Title	Vitamin D and suicidal behavior: Cross-sectional and Mendelian randomization study
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Guo, Lu Dai and Jian Zhan
Funding Agency and Grant Number
Corresponding Author	Jian Zhan, Academic Fellow, Adjunct Professor, Department of Neurology, The Second Affiliated Hospital of Zunyi Medical University, Intersection of Xinlong Avenue and Xinpu Avenue, Honghuagang District, Zunyi 563000, Guizhou Province, China. ghtgyx@126.com
Key Words	25-Hydroxyvitamin D; Suicidal ideation; Suicide attempt; Mendelian randomization; Cross-sectional study
Core Tip	This study utilized a dual-method approach, integrating a cross-sectional analysis of the National Health and Nutrition Examination Survey 2021-2023 data (n = 5089) with bidirectional two-sample Mendelian randomization, to examine the association between vitamin D levels and suicidal behavior. Cross-sectional analysis indicated that lower serum 25-hydroxyvitamin D3 concentrations were independently correlated with an increased likelihood of suicidal ideation (odds ratio = 0.86, 95% confidence interval: 0.76-0.98). Notably, Mendelian randomization analysis suggested that genetically predicted suicide attempts may contribute to decreased vitamin D levels rather than the converse. These findings offer novel insights into the intricate relationship between vitamin D status and suicidal behavior, underscoring the importance of adopting a bidirectional perspective in future research endeavors.
Citation	Guo H, Dai L, Zhan J. Vitamin D and suicidal behavior: Cross-sectional and Mendelian randomization study. World J Psychiatry 2026; In press

Received	2026-06-22 12:04
Peer-Review Started	2026-06-22 12:04
First Decision by Editorial Office Director
Return for Revision	2026-07-03 02:31
Revised	2026-07-11 15:33
Publication Fee Transferred	2026-07-21 11:21
Second Decision by Editor	2026-07-24 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-07-27 07:28
Articles in Press	2026-07-27 07:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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