Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124609
DOI	10.4251/wjgo.124609
Country	Viet Nam

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Risk-stratified screening and prevention for gastric cancer in low- and intermediate-incidence settings: Challenges and pragmatic approaches
Manuscript Source	Invited Manuscript
All Author List	Duc T Quach, Yi-Chia Lee, Shailja C Shah, Carlo A Fallone, Toru Hiyama, Takuji Gotoda, Ernst Kuipers, Kentaro Sugano and Peter Malfertheiner
Funding Agency and Grant Number
Corresponding Author	Duc T Quach, Associate Professor, MD, PhD, Department of Internal Medicine and Gastro-Hepato Integrated Research Team, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, Cho Lon Ward, Ho Chi Minh City 700000, Viet Nam. drquachtd@ump.edu.vn
Key Words	Gastric cancer; Risk stratification; Helicobacter pylori; Endoscopic screening; Risk-based screening
Core Tip	Gastric cancer prevention in low- and intermediate-incidence settings may require alternatives to uniform population-wide endoscopic screening. Population-based Helicobacter pylori screen-and-treat for primary prevention and risk-based endoscopic screening for the detection of premalignant conditions and early neoplasia are complementary but not equivalent strategies. They may be integrated with clinical risk assessment and locally validated biomarkers within context-adapted pathways reflecting local epidemiology, endoscopic capacity, and quality infrastructure. However, direct evidence that such pathways reduce gastric cancer mortality remains limited. Prospective, setting-specific studies are needed to evaluate their clinical effectiveness, cost-effectiveness, feasibility, participation, and equity.
Citation	Quach DT, Lee YC, Shah SC, Fallone CA, Hiyama T, Gotoda T, Kuipers E, Sugano K, Malfertheiner P. Risk-stratified screening and prevention for gastric cancer in low- and intermediate-incidence settings: Challenges and pragmatic approaches. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124609
PDF	124609-in-press.pdf

Received	2026-06-22 03:11
Peer-Review Started	2026-06-22 03:12
First Decision by Editorial Office Director
Return for Revision	2026-08-23 16:19
Revised	2026-09-03 16:40
Publication Fee Transferred
Second Decision by Editor	2026-11-05 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 07:32
Articles in Press	2026-11-05 07:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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