Publication Name	World Journal of Cardiology
Manuscript ID	124700
DOI	10.4330/wjc.124700
Country	Ukraine

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Anchoring composite electrocardiography–heart rate variability indices to a reference standard - the authors’ reply
Manuscript Source	Unsolicited Manuscript
All Author List	Illya A Chaikovsky, Dmytro O Dziuba, Olga A Kryvova, Kyrylo S Malakhov, Oleksandr P Romanchuk, Borys M Todurov and Оleg A Loskutov
Funding Agency and Grant Number
Corresponding Author	Oleksandr P Romanchuk, DM, Full Professor, MD, PhD, Professor, Department of Internal and Family Medicine, Lesya Ukrainka Volyn National University, Bankova Street, 9, Lutsk 43025, Ukraine. romanchuk.oleksandr@vnu.edu.ua
Key Words	Percutaneous coronary intervention; Myocardial injury; Electrocardiography; Heart rate variability; Reference standard; Cardiac troponin; Cardiac magnetic resonance; Validation
Core Tip	Composite electrocardiography and heart rate variability indices can flag small post-procedural changes that the routine 12-lead electrocardiogram misses, but they cannot separate injury from recovery unless anchored to an accepted reference standard. In this reply we set out how that anchor — paired high-sensitivity troponin and late gadolinium enhancement on cardiac magnetic resonance, with injury pre-specified by the Fourth Universal Definition of Myocardial Infarction — will be built into a larger, prospective, presentation-stratified study. We distinguish the validated construction of the composite indices from the exploratory within-cohort clustering, which still requires independent validation before any clinical use.
Citation	Chaikovsky IA, Dziuba DO, Kryvova OA, Malakhov KS, Romanchuk OP, Todurov BM, Loskutov ОA. Letter to the Editor: Anchoring composite electrocardiography–heart rate variability indices to a reference standard - the authors’ reply. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.124700
PDF	124700-in-press.pdf

Received	2026-06-23 05:59
Peer-Review Started	2026-06-23 06:00
First Decision by Editorial Office Director
Return for Revision	2026-08-13 07:20
Revised	2026-08-14 16:55
Publication Fee Transferred
Second Decision by Editor	2026-09-08 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-08 09:55
Articles in Press	2026-09-08 09:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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