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Articles in Press
9/18/2026 10:34:38 AM | Browse: 4 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Weiwikang Formula ameliorates precancerous lesions of gastric cancer: Associations with the HIF-1α/BNIP3 axis, mitophagy, and glycolysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Fang Zhang, Guan-Hua Lv, Cheng-Hui Zhu, Shu-Jian An and Xi-Ran Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Joint Program of the Science and Technology Plan of Liaoning Province (Natural Science Foundation - General Program) |
No. 2024012225-JH4/4800 |
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| Corresponding Author |
Guan-Hua Lv, Director, Full Professor, PhD, Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Provincial Institute of Traditional Chinese Medicine, No. 60 Huanghebei Street, Huanggu District, Shenyang 110031, Liaoning Province, China. 809007025@qq.com |
| Key Words |
Precancerous lesions of gastric cancer; Weiwikang Formula; Hypoxia-inducible factor 1-alpha/B-cell lymphoma 2/adenovirus E1B 19 kDa interacting protein 3 signaling pathway; Mitophagy; Glycolysis |
| Core Tip |
Precancerous lesions of gastric cancer are a pivotal stage in gastric carcinogenesis. In a rat model, Weiwikang Formula ameliorated gastric mucosal injury, intestinal metaplasia, dysplasia, inflammation, and oxidative stress. These effects were accompanied by coordinated changes in hypoxia-inducible factor 1-alpha, B-cell lymphoma 2/adenovirus E1B 19 kDa interacting protein 3, and molecular markers of mitophagy, oxidative phosphorylation, and glycolysis. The findings highlight a potentially relevant molecular network involving hypoxia-inducible factor 1-alpha/B-cell lymphoma 2/adenovirus E1B 19 kDa interacting protein 3 signaling, mitochondrial quality control, and metabolic remodeling, supporting further investigation of Weiwikang Formula as an intervention for precancerous lesions of gastric cancer. |
| Citation |
Zhang XF, Lv GH, Zhu CH, An SJ, Yang XR. Weiwikang Formula ameliorates precancerous lesions of gastric cancer: Associations with the HIF-1α/BNIP3 axis, mitophagy, and glycolysis. World J Gastrointest Oncol 2026; In press
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| PDF |
124725-in-press.pdf
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Received |
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2026-06-23 07:14 |
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Peer-Review Started |
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2026-06-23 07:14 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-22 03:00 |
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Revised |
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2026-07-29 12:55 |
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Publication Fee Transferred |
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2026-08-07 09:34 |
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Second Decision by Editor |
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2026-09-18 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-09-18 10:34 |
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Articles in Press |
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2026-09-18 10:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
