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Articles in Press
10/20/2026 9:40:56 AM | Browse: 10 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Serum hepatitis B virus markers reflect intrahepatic covalently closed circular DNA and transcriptional activity across chronic hepatitis B phases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hye Seon Kim, Jung Eun Jang, Jae Mo Han, Hee Sun Cho, Kwon Yong Tak, Soon Kyu Lee, Ji Won Han, Pil Soo Sung, Sung Won Lee, Jung Hyun Kwon, Si Hyun Bae, Hyun Woong Lee and Jeong Won Jang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Roche Diagnostics Korea |
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| National Research Foundation of Korea Grant Funded by the Korea Government (MSIT) |
RS-2025-00518071 and 2020R1G1A1101354 |
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| Corresponding Author |
Jeong Won Jang, Professor, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, No. 222 Banpo-daero, Seocho-gu, Seoul 06591, South Korea. garden@catholic.ac.kr |
| Key Words |
Hepatitis B virus; Chronic hepatitis B; Biomarkers; Virus replication; Hepatitis B e antigen |
| Core Tip |
This study evaluated the relationship between serum and intrahepatic hepatitis B virus (HBV) markers across all immunological phases of chronic hepatitis B in a large cohort of treatment-naïve patients. Serum hepatitis B core-related antigen and HBV RNA better reflected intrahepatic pregenomic RNA and covalently closed circular DNA (cccDNA) transcriptional activity than hepatitis B surface antigen in a phase-dependent manner. Notably, no serum marker reliably reflected cccDNA transcriptional activity in the Hepatitis B e antigen-negative chronic HBV infection phase, highlighting its virologic heterogeneity. These findings support the phase-specific application of serum biomarkers for the noninvasive assessment and monitoring of intrahepatic HBV activity, with potential implications for therapeutic decision-making. |
| Citation |
Kim HS, Jang JE, Han JM, Cho HS, Tak KY, Lee SK, Han JW, Sung PS, Lee SW, Kwon JH, Bae SH, Lee HW, Jang JW. Serum hepatitis B virus markers reflect intrahepatic covalently closed circular DNA and transcriptional activity across chronic hepatitis B phases. World J Gastroenterol 2026; In press
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| PDF |
124758-in-press.pdf
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Received |
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2026-06-24 07:38 |
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Peer-Review Started |
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2026-06-24 07:38 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-16 09:19 |
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Revised |
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2026-07-30 06:59 |
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Publication Fee Transferred |
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2026-09-11 05:25 |
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Second Decision by Editor |
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2026-10-20 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-10-20 09:40 |
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Articles in Press |
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2026-10-20 09:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
