Publication Name	World Journal of Hepatology
Manuscript ID	124763
DOI	10.4254/wjh.124763
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Imbalance of the coagulation-anticoagulation-fibrinolytic system: Pathogenesis and therapeutic approaches in progressive liver injury
Manuscript Source	Invited Manuscript
All Author List	Yong-Jing Tang, Chen-Xi Wang, Yun Wen, Ren-Dong Tian, Dian-Wei Wan, Zong-Qin Pan, Kang-Yan Liu, Yu-Xin Xie, Jin Ao and Yi-Huai He
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Planning Projects of Guizhou Province QKHJC-MS(2025)384, QKHJC-MS(2025)392 Health Research Project of Guizhou Province gzwkj2024-103, gzwkj2024-324 Scientific Research Project of the Guizhou Provincial Bureau of Traditional Chinese Medicine QZYY-2023-021 Chinese Foundation for Hepatitis Prevention and Control Muxin Research Fund of CHB MX202404 Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund iGandanF-1082024-RGG018
Corresponding Author	Yi-Huai He, MD, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi 563000, Guizhou Province, China. 993565989@qq.com
Key Words	Coagulation-anticoagulation-fibrinolysis system; Liver injury; Rebalanced state; Intrahepatic microcirculatory disturbance; Portal vein thrombosis; Coagulopathy; Therapeutic strategies
Core Tip	During the progression of liver injury, an imbalance in the coagulation-anticoagulation-fibrinolysis cascade results in a complex hemostatic state: Systemic hypocoagulability with bleeding tendency vs intrahepatic and portal hypercoagulability with thrombotic risk. This dichotomy drives microcirculatory dysfunction, portal vein thrombosis, and disease aggravation. This review summarizes the dynamics of these changes, their pathological implications, and therapeutic interventions, offering a theoretical backing for the management of liver injury.
Citation	Tang YJ, Wang CX, Wen Y, Tian RD, Wan DW, Pan ZQ, Liu KY, Xie YX, Ao J, He YH. Imbalance of the coagulation-anticoagulation-fibrinolytic system: Pathogenesis and therapeutic approaches in progressive liver injury. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124763
PDF	124763-in-press.pdf

Received	2026-06-24 07:04
Peer-Review Started	2026-06-24 07:04
First Decision by Editorial Office Director
Return for Revision	2026-07-22 04:12
Revised	2026-08-13 12:51
Publication Fee Transferred
Second Decision by Editor	2026-09-22 03:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-22 09:58
Articles in Press	2026-09-22 09:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com