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Articles in Press
8/10/2026 11:00:08 AM | Browse: 6 | Download: 0
| Category |
Ophthalmology |
| Manuscript Type |
Editorial |
| Article Title |
PRDX2 and Müller cells in diabetic retinopathy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Francesco Cappellani, Matteo Capobianco, Antonio M. Vicari and Marco Zeppieri |
| Funding Agency and Grant Number |
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| Corresponding Author |
Marco Zeppieri, Consultant, MD, PhD, Postdoc, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it |
| Key Words |
Müller glial cells; Diabetic retinopathy; RhoA/ROCK signaling; Peroxiredoxin-2; Redox dysregulation |
| Core Tip |
The emerging role of Müller cell dysfunction anticipating and worsening diabetic retinopathy is increasingly acknowledged. The altered redox balance in Müller glial hyperreactivity triggering the RhoA/ROCK pathway was widely demonstrated by Du et al with peroxiredoxin-2 (PRDX2). This article offers an overview of the PRDX2-related cytoskeletal reorganization and glial proliferation, moreover it suggests a different perspective above the conventional role of antioxidant enzymes and suggests also some future perspective for new targeted therapies to contrast gliosis effects and preserving neurovascular health. |
| Citation |
Cappellani F, Capobianco M, Vicari AM, Zeppieri M. PRDX2 and Müller cells in diabetic retinopathy. World J Diabetes 2026; In press
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| PDF |
124773-in-press.pdf
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Received |
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2026-06-24 01:30 |
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Peer-Review Started |
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2026-06-25 23:56 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-07-07 02:40 |
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Revised |
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2026-07-10 10:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-08-06 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-08-10 11:00 |
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Articles in Press |
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2026-08-10 11:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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