Publication Name	World Journal of Hepatology
Manuscript ID	124800
Country	India

Category	Oncology
Manuscript Type	Review
Article Title	Molecular pathophysiology of hepatocellular carcinoma: Role of tumor microenvironment and vascular signaling
Manuscript Source	Invited Manuscript
All Author List	Deepti Sharma, Babu Lal Meena and Vanya Garg
Funding Agency and Grant Number
Corresponding Author	Deepti Sharma, Additional Professor, Department of Radiation Oncology, Institute of Liver and Biliary Sciences, Vasant Kuunj, New Delhi 110070, India. drdeeptisharma16@gmail.com
Key Words	Hepatocellular carcinoma; Tumor microenvironment; Vascular endothelial growth factor; Hypoxia-inducible factors; Immune checkpoint inhibitors
Core Tip	Hepatocellular carcinoma (HCC) progression is governed by dynamic interactions between tumor genomics, stromal elements, hypoxia, and aberrant vascular signaling. The success of immune-antiangiogenic combinations validates the concept that vascular normalization and immune reprogramming are biologically interconnected processes. This review integrates molecular, tumor microenvironment-level, and clinical trial data to define biomarker-aligned, mechanism-based vascular and immune targeting strategies aimed at achieving more durable disease control in advanced HCC.
Citation	Sharma D, Meena BL, Garg V. Molecular pathophysiology of hepatocellular carcinoma: Role of tumor microenvironment and vascular signaling. World J Hepatol 2026; In press

Received	2026-06-24 07:04
Peer-Review Started	2026-06-24 07:04
First Decision by Editorial Office Director
Return for Revision	2026-07-20 08:51
Revised	2026-08-01 16:00
Publication Fee Transferred
Second Decision by Editor	2026-10-10 03:25
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-10 09:11
Articles in Press	2026-10-10 09:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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