Publication Name	World Journal of Critical Care Medicine
Manuscript ID	124802
DOI	10.5492/wjccm.124802
Country	United States

Category	Critical Care Medicine
Manuscript Type	Retrospective Cohort Study
Article Title	Use of reversal agents for factor xa inhibitors and progression of traumatic intracranial hemorrhage: A propensity matched analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Benjamin O’Brien, Weng Chan, Larissa Russo and Nasim Ahmed
Funding Agency and Grant Number
Corresponding Author	Nasim Ahmed, FACS, Full Professor, Department of Surgery, Division of Trauma and Surgical Critical Care, Jersey Shore University Medical Center, 1945 State Rt. 33, Neptune, NJ 07753, United States. nasim.ahmed@hmhn.org
Key Words	Traumatic intracranial hemorrhage; Factor Xa inhibitors; Four-factor prothrombin complex concentrate; Andexanet alfa; Progression of hemorrhage
Core Tip	The purpose of the study was to assess which reversal agent, four-factor prothrombin complex concentrate or andexanet alfa, had a better effect on expansion of intracranial hemorrhage (ICH) in patients who received direct oral anticoagulants. Andexanet alfa was found to have better effect on expansion of ICH (25.5% vs 41.2%, P = 0.226), however statistically found no difference. Larger sample size studies are needed to determine which reversal agent has better efficacy in preventing expansion of traumatic ICH.
Citation	O’Brien B, Chan W, Russo L, Ahmed N. Use of reversal agents for factor xa inhibitors and progression of traumatic intracranial hemorrhage: A propensity matched analysis. World J Crit Care Med 2026; In press DOI: https://doi.org/10.5492/wjccm.124802
PDF	124802-in-press.pdf

Received	2026-06-24 07:38
Peer-Review Started	2026-06-24 07:39
First Decision by Editorial Office Director
Return for Revision	2026-07-21 02:48
Revised	2026-08-04 12:45
Publication Fee Transferred
Second Decision by Editor	2026-09-15 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-15 09:33
Articles in Press	2026-09-15 09:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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