Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	124805
Country	Egypt

Category	Nutrition & Dietetics
Manuscript Type	Randomized Controlled Trial
Article Title	Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Walaa E M A Morsi, Ayman E Eskander, Mohamed G Mostafa, Zahraa Ezz ElDin, Fatma A Abdel Maksoud and Amira Elrefaee
Funding Agency and Grant Number
Corresponding Author	Amira Elrefaee, Lecturer, MD, Department of Pediatrics, Faculty of Medicine, Cairo University, Kasr Al Ainy Faculty of Medicine, Al-Manial, Cairo 11956, Al Qāhirah, Egypt. amiraelrefaee@cu.edu.eg
Key Words	Lactase supplementation; Preterm infants; Feeding intolerance; Weight gain; Necrotizing enterocolitis
Core Tip	This randomized, double-blind controlled trial evaluated lactase enzyme supplementation in preterm infants born before 34 weeks of gestation. Lactase supplementation improved feeding tolerance by reducing gastric residuals, abdominal distension, emesis, and diarrhea. It was also associated with improved stool reducing-substance results, higher fecal pH, and greater daily weight gain. In addition, fewer infants developed necrotizing enterocolitis in the lactase group. These findings suggest that lactase supplementation may be a safe and useful adjunct to enteral feeding in preterm infants.
Citation	Morsi WEMA, Eskander AE, Mostafa MG, Ezz ElDin Z, Abdel Maksoud FA, Elrefaee A. Early lactase enzyme supplementation: Efficacy to promote growth and feeding tolerance in preterm infants: A randomized controlled trial. World J Clin Pediatr 2026; In press

Received	2026-06-24 07:38
Peer-Review Started	2026-06-24 07:39
First Decision by Editorial Office Director
Return for Revision	2026-07-24 01:20
Revised	2026-08-06 15:46
Publication Fee Transferred	2026-08-10 09:28
Second Decision by Editor	2026-08-26 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-26 08:59
Articles in Press	2026-08-26 08:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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