Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124848
DOI	10.4251/wjgo.124848
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Thyroid-like intrahepatic cholangiocarcinoma, a rare subtype with distinct clinicopathological and molecular features: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Lian-Mei Zhang, Xiao-Wen Gu, Huan-Yu Zhao, Xue Gong and Ya-Ning Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Huaian Science and Technology Plan Project No. HAB2024004 Huai'an Natural Science Research Joint Program No. HABL202241
Corresponding Author	Ya-Ning Zhu, Affiliate Associate Professor, Associate Chief Physician, Researcher, Department of Pathology, The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, No. 1 West Huanghe Road, Huaiyin District, Huai’an 223300, Jiangsu Province, China. 03nan.cy@163.com
Key Words	Thyroid-like intrahepatic cholangiocarcinoma; Rare liver tumor; Immunohistochemistry; CHEK2 mutation; ERBB2 alteration; CDK12 variant; Case report
Core Tip	Thyroid-like intrahepatic cholangiocarcinoma is a rare variant that morphologically mimics thyroid follicular neoplasms. We report a case with comprehensive clinicopathological and molecular characterization. The tumor demonstrated positive staining for biliary markers and inhibin alpha, with negativity for thyroid markers. Next-generation sequencing revealed mutations in CHEK2, CDK12, and ERBB2, suggesting a distinct molecular profile from conventional cholangiocarcinoma. This case highlights the diagnostic challenges and the importance of integrating histology, immunohistochemistry, and molecular testing for accurate diagnosis.
Citation	Zhang LM, Gu XW, Zhao HY, Gong X, Zhu YN. Thyroid-like intrahepatic cholangiocarcinoma, a rare subtype with distinct clinicopathological and molecular features: A case report. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124848
PDF	124848-in-press.pdf

Received	2026-06-25 08:29
Peer-Review Started	2026-06-25 08:29
First Decision by Editorial Office Director
Return for Revision	2026-07-10 01:45
Revised	2026-08-02 15:09
Publication Fee Transferred	2026-08-19 11:43
Second Decision by Editor	2026-10-08 07:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-08 09:54
Articles in Press	2026-10-08 09:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com