Publication Name	World Journal of Cardiology
Manuscript ID	124876
DOI	10.4330/wjc.124876
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Cardiovascular aging as a modifiable biological process: Mechanisms, clinical phenotypes, and translational opportunities
Manuscript Source	Invited Manuscript
All Author List	Qing Liu, Yi-Fei Wang, Yu Geng, Ping Zhang and Ting-Ting Lv
Funding Agency and Grant Number
Corresponding Author	Ting-Ting Lv, Associate Research Scientist, Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Changping District, Beijing 102218, China. lvtingting0616@163.com
Key Words	Cardiovascular aging; Geroscience; Hallmarks of aging; Translational medicine; Biomarkers; Intervention
Core Tip	This review synthesizes current evidence that cardiovascular aging is driven by interconnected hallmarks: Cellular senescence, mitochondrial dysfunction, epigenetic remodeling, telomere attrition, and impaired proteostasis which converge on atherosclerosis, heart failure with preserved ejection fraction, hypertension, and arrhythmia. We highlight emerging assessment tools including imaging-based indices, circulating biomarkers, and epigenetic clocks for quantifying biological age, and critically evaluate geroprotective strategies ranging from lifestyle modification to senotherapeutics and nicotinamide adenine dinucleotide/mechanistic target of rapamycin modulation. Bridging geroscience principles with cardiovascular medicine, this review positions cardiovascular aging as a clinically modifiable target for promoting healthy longevity.
Citation	Liu Q, Wang YF, Geng Y, Zhang P, Lv TT. Cardiovascular aging as a modifiable biological process: Mechanisms, clinical phenotypes, and translational opportunities. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.124876
PDF	124876-in-press.pdf

Received	2026-06-26 06:12
Peer-Review Started	2026-06-26 06:15
First Decision by Editorial Office Director
Return for Revision	2026-06-29 05:42
Revised	2026-07-13 04:21
Publication Fee Transferred
Second Decision by Editor	2026-08-20 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-20 09:13
Articles in Press	2026-08-20 09:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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