Publication Name	World Journal of Hepatology
Manuscript ID	124890
DOI	10.4254/wjh.124890
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	When the Gut Speaks, the Liver Listens: Pathogenesis, Diagnostic Spectrum, and Artificial Intelligence Guided Interventions in Colitis-Driven Hepatopathies
Manuscript Source	Invited Manuscript
All Author List	Roobee Garla, Tanvi Sharma, Monika Sharma and Naveen Kaushal
Funding Agency and Grant Number	Funding Agency Grant Number DHR Women Scientist Fellowship 12013/53/2024 Council of Scientific and Industrial Research (CSIR) 09/0135 (23752)/2025-EMR-I Indian Council of Medical Research (ICMR) EM/Dev/SG/35/02481/2024
Corresponding Author	Roobee Garla, Post Doctoral Researcher, Department of Biophysics, South Campus, Panjab University, BMS Block II, Sector 25, Chandigarh 160014, Union Territory, India. rubygarla@gmail.com
Key Words	Inflammatory bowel disease; Gut-liver axis; Liver disorders; Therapies; Artificial intelligence
Core Tip	Intestinal inflammation disrupts the gut-liver axis at multiple levels, compromising the physiological crosstalk. Microbial dysbiosis, bile acid dysmetabolism, and intestinal barrier failure all converge on the liver and biliary system, causing a variety of diseases, from the most mechanistically precise disease, primary sclerosing cholangitis, to the most prevalent yet often ignored metabolic dysfunction-associated steatotic liver disease. In addition to investigating the diagnostic overlap between primary sclerosing cholangitis, its mimics, and primary biliary cholangitis, this article discusses how new artificial intellegence-driven diagnostic techniques may help close existing gaps in early diagnosis and risk stratification.
Citation	Garla R, Sharma T, Sharma M, Kaushal N. When the gut speaks, the liver listens: Pathogenesis, diagnostic spectrum, and artificial intelligence guided interventions in colitis-associated hepatopathies. World J Hepatol 2026; In press DOI: https://doi.org/10.4254/wjh.124890
PDF	124890-in-press.pdf

Received	2026-06-29 02:23
Peer-Review Started	2026-06-29 02:23
First Decision by Editorial Office Director
Return for Revision	2026-09-11 07:39
Revised	2026-09-23 12:39
Publication Fee Transferred
Second Decision by Editor	2026-11-05 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 07:33
Articles in Press	2026-11-05 07:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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