Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124919
DOI	10.4251/wjgo.124919
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Colorectal metastases from gastric adenocarcinoma: A single-center retrospective study of diagnostic challenges, clinicopathologic features, and clinical outcomes
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Jung Chen, Po-Jung Chen, Yen-Cheng Chen, Chi-Han Yang, Tsung-Kun Chang, Wei-Chih Su, Ching-Wen Huang, Hsiang-Lin Tsai and Jaw-Yuan Wang
Funding Agency and Grant Number	Funding Agency Grant Number Mentor‑Guided Research Project of Chung‑Ho Memorial Hospital, Kaohsiung Medical University KMUH114-4M34, KMUH114-4R37, KMUH114-4M35 Mentor‑Guided Research Project of Chung‑Ho Memorial Hospital, Kaohsiung Medical University KMUH114-4R38, KMUH113-3R31, KMUH113-3R32 Mentor‑Guided Research Project of Chung‑Ho Memorial Hospital, Kaohsiung Medical University KMUH113-3R33, KMUH113-3M58, KMUH113-3M59
Corresponding Author	Jaw-Yuan Wang, MD, PhD, Professor, Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung 80708, Taiwan. cy614112@ms14.hinet.net
Key Words	Gastric adenocarcinoma; Colorectal metastasis; Synchronous metastasis; Metachronous metastasis; Retrospective study
Core Tip	Colorectal metastasis from gastric cancer is an exceptionally rare entity that frequently mimics primary colorectal carcinoma, creating substantial diagnostic challenges. In this retrospective study of six patients, we characterized the clinicopathologic features, immunohistochemical profiles, treatment strategies, and survival outcomes of this uncommon metastatic pattern. Our findings demonstrate considerable heterogeneity in cytokeratin 7, cytokeratin 20, and caudal-type homeobox 2 expression, emphasizing that immunohistochemistry should always be interpreted together with morphologic features and clinical history. Despite multimodal treatment, prognosis remained poor, although very late metastasis can occur more than 10 years after initial gastric cancer diagnosis.
Citation	Chen YJ, Chen PJ, Chen YC, Yang CH, Chang TK, Su WC, Huang CW, Tsai HL, Wang JY. Colorectal metastases from gastric adenocarcinoma: A single-center retrospective study of diagnostic challenges, clinicopathologic features, and clinical outcomes. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124919
PDF	124919-in-press.pdf

Received	2026-06-26 07:57
Peer-Review Started	2026-06-26 07:58
First Decision by Editorial Office Director
Return for Revision	2026-07-13 08:19
Revised	2026-07-24 05:59
Publication Fee Transferred
Second Decision by Editor	2026-08-17 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-17 09:38
Articles in Press	2026-08-17 09:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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