Publication Name	World Journal of Clinical Oncology
Manuscript ID	124935
DOI	10.5306/wjco.124935
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	HN1 L promotes colorectal cancer proliferation and migration by inhibiting the Hippo pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Da Kang, Ling-Xin Zeng, Rong-Xin Zhang, Wen-Juan Ma, Rong Yang and Xin Wang
Funding Agency and Grant Number	Funding Agency Grant Number 2020 Annual Open Research Fund of the Sixth Affiliated Hospital of Guangzhou Medical University No. 202011-103 and No. 202301-314 2022 Special Fund of Qingyuan People’s Hospital No. QYRYCRC2023015
Corresponding Author	Xin Wang, MD, Professor, Department of Oncology, The Affiliated Qingyuan Hospital(Qingyuan People's Hospital), Guangzhou Medical University, No.35, Yinquan North Road, Qingcheng District, Qingyuan 511518, Guangdong Province, China. xinwang@gzhmu.edu.cn
Key Words	Colorectal cancer; HN1 L; Hippo pathway; Adjuvant therapy; Prognosis
Core Tip	This study identifies HN1 L as an oncogenic regulator in colorectal cancer (CRC). Integrated transcriptomic, cellular, xenograft, and clinical analyses demonstrate that HN1 L enhances CRC proliferation and migration by inhibiting Hippo pathway activity, primarily through reduced MOB1 and YAP phosphorylation. Clinically, high HN1 L expression was associated with poorer five-year overall survival, while an exploratory interaction analysis suggested a possible difference in adjuvant chemotherapy benefit according to HN1 L expression. These findings suggest that HN1 L may function as a chemotherapy-response indicator and a potential therapeutic target in CRC.
Citation	Kang D, Zeng LX, Zhang RX, Ma WJ, Yang R, Wang X. HN1 L promotes colorectal cancer proliferation and migration by inhibiting the Hippo pathway. World J Clin Oncol 2026; In press DOI: https://doi.org/10.5306/wjco.124935
PDF	124935-in-press.pdf

Received	2026-06-30 08:44
Peer-Review Started	2026-06-30 08:44
First Decision by Editorial Office Director
Return for Revision	2026-07-17 03:11
Revised	2026-08-14 05:42
Publication Fee Transferred
Second Decision by Editor	2026-10-22 03:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-22 09:06
Articles in Press	2026-10-22 09:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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