Publication Name	World Journal of Translational Medicine
Manuscript ID	124965
DOI	10.5528/wjtm.124965
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatic exposome as an emerging contributor to metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Ahmed Salman, Ahmed Elewa, Ahmad Marwan and Mohamed A Salman
Funding Agency and Grant Number
Corresponding Author	Ahmed Salman, FRACP, FRCP, Department of Internal Medicine, Faculty of Medicine, Cairo University, Zahraa El Maadi, Abrag Degla Masr, Building 46, Fourth Floor, Apartment 41, Near to Kuwaiti Mosque, 11742, Cairo 12111, Egypt. awea844@gmail.com
Key Words	Exposome; Steatotic liver disease; Metabolic dysfunction-associated steatotic liver disease; Per- and polyfluoroalkyl substances; Microplastics; Endocrine-disrupting chemicals; Environmental pollutants; Hepatocellular carcinoma; Environmental hepatology
Core Tip	Metabolic dysfunction-associated steatotic liver disease is typically a result of overnutrition and metabolic syndrome; the phenomenon of lean disease and its increasing prevalence remain inadequately elucidated. This review analyzes the hepatic exposome, focusing on environmental chemicals such as per- and polyfluoroalkyl substances, phthalates, bisphenols, persistent organic pollutants, toxic metals, and air pollution as potential modifiable factors contributing to steatosis, steatohepatitis, fibrosis, and hepatocellular carcinoma, while also noting that micro- and nanoplastics remain an emerging and unverified exposure. We incorporated shared mechanisms, human and experimental evidence assessed by strength, sex-specific susceptibility, and the tools necessary to implement environmental hepatology in practice.
Citation	Salman A, Elewa A, Marwan A, Salman MA. Hepatic exposome as an emerging contributor to metabolic dysfunction-associated steatotic liver disease. World J Transl Med 2026; In press DOI: https://doi.org/10.5528/wjtm.124965
PDF	124965-in-press.pdf

Received	2026-06-29 03:22
Peer-Review Started	2026-06-29 03:22
First Decision by Editorial Office Director
Return for Revision	2026-07-21 11:46
Revised	2026-07-30 10:13
Publication Fee Transferred
Second Decision by Editor	2026-08-31 03:15
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-31 08:47
Articles in Press	2026-08-31 08:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6132 (online)
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