Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	124979
DOI	10.4251/wjgo.124979
Country	China

Category	Oncology
Manuscript Type	Review
Article Title	Targeting glycogen synthase kinase-3β in pancreatic ductal adenocarcinoma: Mechanisms and clinical translation
Manuscript Source	Invited Manuscript
All Author List	Zi-Ke Zhang, Sen-Bang Yao, Hao Sun, Chao Wang and Hao-Jun Huang
Funding Agency and Grant Number
Corresponding Author	Hao-Jun Huang, Doctorate Student, School of Nursing, Yanbian University, No. 977 Gongyuan Road, Yanji 133000, Jilin Province, China. hy86382211@163.com
Key Words	Glycogen synthase kinase-3β; Pancreatic ductal adenocarcinoma; Elraglusib; Chemotherapy sensitization; Biomarkers
Core Tip	Glycogen synthase kinase-3β links pancreatic ductal adenocarcinoma survival to replication-stress tolerance and substrate turnover. Its therapeutic value depends on which kinase-dependent functions sustain the tumor during treatment. Elraglusib’s randomized phase II survival finding supports confirmatory testing, with progression, toxicity, and chemotherapy delivery assessed together. Distinguishing its kinase and microtubule activities, and relating tumor pharmacodynamics to added clinical benefit, are priorities for combination development and patient selection.
Citation	Zhang ZK, Yao SB, Sun H, Wang C, Huang HJ. Targeting glycogen synthase kinase-3β in pancreatic ductal adenocarcinoma: Mechanisms and clinical translation. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.124979
PDF	124979-in-press.pdf

Received	2026-07-02 05:53
Peer-Review Started	2026-07-02 05:53
First Decision by Editorial Office Director
Return for Revision	2026-08-08 09:09
Revised	2026-08-22 08:10
Publication Fee Transferred
Second Decision by Editor	2026-11-02 02:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-04 10:25
Articles in Press	2026-11-04 10:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com