Publication Name	World Journal of Transplantation
Manuscript ID	124992
DOI	10.5500/wjt.124992
Country	Greece

Category	Transplantation
Manuscript Type	Review
Article Title	Pathophysiological mechanisms of cell death affecting graft survival in liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Athanasios Kofinas, Alexandra G Marneri, Kalliopi E Stavrati, Georgios Tsoulfas and Theodoros E Pavlidis
Funding Agency and Grant Number
Corresponding Author	Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words	Liver transplantation; Early allograft dysfunction; Hepatic ischemia-reperfusion injury; Cell death; Graft injury; Hepatocellular damage pathways
Core Tip	The incidence of end-stage liver disease and its associated mortality have increased substantially in recent years, with liver transplantation remaining the sole definitive therapeutic intervention for affected patients. Hepatic ischemia-reperfusion injury is implicated strongly in early allograft dysfunction (EAD), increased postoperative complications, and unfavorable long-term prognoses. It affects nearly all grafts to varying extents, with the severity of injury being correlated with elevated morbidity, primary graft dysfunction, and potential graft loss. The prevention and immediate recognition of EAD, along with a thorough understanding of its pathophysiological processes, are crucial for optimal transplant function.
Citation	Mouratidou C, Pavlidis ET, Katsanos G, Kofinas A, Marneri AG, Stavrati KE, Tsoulfas G, Pavlidis TE. Pathophysiological mechanisms of cell death affecting graft survival in liver transplantation. World J Transplant 2026; In press DOI: https://doi.org/10.5500/wjt.124992
PDF	124992-in-press.pdf

Received	2026-06-29 09:42
Peer-Review Started	2026-06-29 09:43
First Decision by Editorial Office Director
Return for Revision	2026-07-17 02:35
Revised	2026-07-24 17:57
Publication Fee Transferred
Second Decision by Editor	2026-08-06 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-10 11:11
Articles in Press	2026-08-10 11:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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