Publication Name	World Journal of Transplantation
Manuscript ID	125021
DOI	10.5500/wjt.125021
Country	Pakistan

Category	Transplantation
Manuscript Type	Minireviews
Article Title	Role of natural killer cells in antibody mediated rejection in kidney transplantation
Manuscript Source	Invited Manuscript
All Author List	Khawar Abbas, Wajiha Musharraf, Muhammed Mubarak and Rubina Naqvi
Funding Agency and Grant Number
Corresponding Author	Khawar Abbas, Full Professor, Professor, Department of Immunology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drkhawar_imuno@yahoo.com
Key Words	Kidney transplantation; Antibody-mediated rejection; Natural killer cells; Donor-specific antibodies; Antibody-dependent cellular cytotoxicity; Microvascular inflammation
Core Tip	Antibody-mediated rejection remains a major cause of long-term kidney allograft dysfunction and graft failure despite advances in immunosuppressive therapy. Antibody-mediated rejection has been attributed primarily to donor-specific antibodies and complement-mediated endothelial injury, but growing evidence indicates that natural killer (NK) cells can also play an important role in mediating allograft injury. NK cells contribute to endothelial damage through antibody-dependent cellular cytotoxicity via FcγRIIIa (CD16) engagement and through antibody-independent mechanisms such as missing-self recognition. Activated NK cells release cytotoxic molecules and pro-inflammatory cytokines that promote microvascular inflammation, glomerulitis, and chronic vascular injury.
Citation	Abbas K, Musharraf W, Mubarak M, Naqvi R. Role of natural killer cells in antibody mediated rejection in kidney transplantation. World J Transplant 2026; In press DOI: https://doi.org/10.5500/wjt.125021
PDF	125021-in-press.pdf

Received	2026-07-02 02:52
Peer-Review Started	2026-07-02 02:53
First Decision by Editorial Office Director
Return for Revision	2026-07-15 03:13
Revised	2026-07-22 04:42
Publication Fee Transferred
Second Decision by Editor	2026-09-04 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-04 10:22
Articles in Press	2026-09-04 10:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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