Publication Name	World Journal of Diabetes
Manuscript ID	125169
DOI	10.4239/wjd.125169
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Netrin-4 promotes pancreatic β-cell proliferation and insulin secretion in obesity by regulating translationally controlled tumor protein 1
Manuscript Source	Unsolicited Manuscript
All Author List	Xia Wang, Ya-Ni Shi, Ming-Shan Shuai, Shan Geng, Xiang-Fen Chen, Meng-Ling Zhang, Dan-Lan Pu and Qi-Nan Wu
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Science and Health Joint Medical Research General Project 2026MSXM024 Science and Health Joint Project of Dazu District Science and Technology Bureau DZKJ2024JSYJ-KWXM1002 Research project of the State Administration of Traditional Chinese Medicine on collaborative chronic disease management of traditional Chinese medicine and western medicine CXZH2024087 Chongqing Medical Leading Talent Project YXLJ202514 Chronic Disease Management Research Project of National Health Commission Capacity Building and Continuing Education Center GWJJMB202510024191 General project of Chongqing Natural Science Foundation CSTB2023NSCQ-MSX0246
Corresponding Author	Qi-Nan Wu, Chief Physician, PhD, Department of Endocrinology, The Affiliated Dazu’s Hospital of Chongqing Medical University, The People’s Hospital of Dazu, No. 1073 Second Ring South Road, Hongxing Community, Tangxiang Street, Dazu District, Chongqing 402360, China. wqn11@126.com
Key Words	Netrin-4; β-cell proliferation; Insulin secretion; Insulin resistance; Obesity
Core Tip	This study establishes that netrin-4 (NTN4) expression is markedly downregulated in pancreatic islets under obesity-associated lipotoxic stress. Mechanistically, NTN4 preserves pancreatic β-cell homeostasis through interaction with translationally controlled tumor protein 1 (TPT1), which consequently increases TPT1-mediated functional output. These findings delineate the NTN4-TPT1 regulatory axis as a critical pathophysiological node in obesity-associated diabetes; therefore, this signaling module should be considered for further evaluation as a viable therapeutic entry point.
Citation	Wang X, Shi YN, Shuai MS, Geng S, Chen XF, Zhang ML, Pu DL, Wu QN. Netrin-4 promotes pancreatic β-cell proliferation and insulin secretion in obesity by regulating translationally controlled tumor protein 1. World J Diabetes 2026; In press DOI: https://doi.org/10.4239/wjd.125169
PDF	125169-in-press.pdf

Received	2026-06-30 03:20
Peer-Review Started	2026-07-02 00:01
First Decision by Editorial Office Director
Return for Revision	2026-08-05 04:12
Revised	2026-09-06 13:44
Publication Fee Transferred	2026-10-14 10:02
Second Decision by Editor	2026-11-02 02:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-02 03:18
Articles in Press	2026-11-02 03:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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