Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	125207
Country	China

Category	Immunology
Manuscript Type	Review
Article Title	Ferroptosis in colorectal cancer: Molecular mechanisms, therapeutic opportunities, and challenges
Manuscript Source	Unsolicited Manuscript
All Author List	Jian Kang, Meng Zhang, Chang-Yan Geng, Hao Yang, Zhe Li and Bing Yu
Funding Agency and Grant Number
Corresponding Author	Bing Yu, Chief Physician, PhD, Department of the Colorectal Anal Surgery, The Affiliated Tai’an City Central Hospital of Qingdao University, No. 29 Longtan Road, Tai’an 271000, Shandong Province, China. yubing43210@163.com
Key Words	Colorectal cancer; Ferroptosis; Lipid peroxidation; Ferroptosis resistance; Immunotherapy; Immune checkpoint inhibitors; Drug resistance; Tumor microenvironment
Core Tip	Ferroptosis is a form of cell death driven by iron-dependent lipid peroxidation, and its regulation involves iron metabolism, lipid remodeling, and glutathione peroxidase 4-centered antioxidant systems. In colorectal cancer cells, this process is further modulated by the signaling pathways of acyl-CoA synthetase long-chain family member 4, AMP-activated protein kinase, and nuclear factor erythroid 2-related factor 2. Ferroptosis reshapes the immunosuppressive tumor microenvironment through damage-associated molecular patterns-mediated immunogenic cell death, enhancing CD8+ T cell-mediated anti-tumor immunity; however, excessive lipid peroxides can compromise effector T cell viability. Ferroptosis-inducing combination therapy potently overcomes resistance to chemotherapies, targeted agents, and immune checkpoint inhibitors. Key translational challenges include tumor heterogeneity, the lack of ferroptosis-specific biomarkers, and off-target intestinal toxicity, which may be partially addressed through tumor-targeted nanomedicine and multi-omics patient stratification.
Citation	Kang J, Zhang M, Geng CY, Yang H, Li Z, Yu B. Ferroptosis in colorectal cancer: Molecular mechanisms, therapeutic opportunities, and challenges. World J Gastrointest Oncol 2026; In press

Received	2026-07-02 07:34
Peer-Review Started	2026-07-02 07:35
First Decision by Editorial Office Director
Return for Revision	2026-08-06 03:01
Revised	2026-08-25 05:48
Publication Fee Transferred	2026-09-28 07:58
Second Decision by Editor	2026-10-27 03:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-28 01:17
Articles in Press	2026-10-28 01:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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