Publication Name	World Journal of Cardiology
Manuscript ID	125211
DOI	10.4330/wjc.125211
Country	Russia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Cardiorespiratory coordination: History of the development of analysis methods, current state and study prospects
Manuscript Source	Invited Manuscript
All Author List	Elizaveta S Dubinkina and Anton R Kiselev
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation 25-44-10019
Corresponding Author	Anton R Kiselev, Head, Professor, Coordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, str. 3, Moscow 101990, Moskva, Russia. antonkis@list.ru
Key Words	Cardiovascular system; Respiration; Cardiorespiratory coordination; Coordigram; Hypertension
Core Tip	This review systematizes the development of cardiorespiratory coordination (CRC) analysis methods from 1966 to 2024, highlighting its advantages over respiratory sinus arrhythmia and cardiorespiratory phase synchronization. Unlike these methods, CRC does not require phase detection, is robust to irregular rhythms, and enables directionality assessment. The review identifies a critical gap-no direct CRC studies in arterial hypertension, myocardial infarction, chronic ischemic heart disease, chronic obstructive pulmonary disease, or bronchial asthma-and puts forward competing hypotheses grounded in pathophysiological mechanisms. It ultimately advocates for experimental studies to explore CRC’s diagnostic potential in these conditions.
Citation	Dubinkina ES, Kiselev AR. Cardiorespiratory coordination: History of the development of analysis methods, current state and study prospects. World J Cardiol 2026; In press DOI: https://doi.org/10.4330/wjc.125211
PDF	125211-in-press.pdf

Received	2026-07-03 03:17
Peer-Review Started	2026-07-03 03:18
First Decision by Editorial Office Director
Return for Revision	2026-08-03 08:27
Revised	2026-08-17 14:00
Publication Fee Transferred
Second Decision by Editor	2026-08-28 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-08-28 10:25
Articles in Press	2026-08-28 10:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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