Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	125213
DOI	10.4251/wjgo.125213
Country	Türkiye

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	FBXW7 mutation is associated with poor overall survival in metastatic colorectal carcinoma: A retrospective single-center next-generation sequencing cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Sevil Karabağ, Meltem Öznur, Yıldız Garip Bilen and Okan Avci
Funding Agency and Grant Number
Corresponding Author	Sevil Karabağ, Associate Professor, Department of Pathology, Tekirdag Namık Kemal University, Namık Kemal Street, Tekirdağ 59030, Türkiye. skarabag@nku.edu.tr
Key Words	Metastatic colorectal carcinoma; Tumor sidedness; Next-generation sequencing; FBXW7 mutation; BRAF mutation; Overall survival; Prognostic association; Retrospective cohort
Core Tip	This retrospective, single-center cohort study evaluated the prognostic relevance of molecular alterations detected by next-generation sequencing in 208 patients with metastatic colorectal carcinoma (CRC). BRAF mutations were more frequent in right-sided tumors and were associated with shorter overall survival (OS) in the Kaplan-Meier analysis but were not associated with OS after multivariable adjustment. The FBXW7 mutation, although infrequent, was associated with shorter OS after adjustment for the available covariates. These findings provide hypothesis-generating support for the prognostic relevance of FBXW7 mutation in metastatic CRC and extend previous mutation-based observations, while underscoring the need for validation in larger, clinically well-characterized cohorts.
Citation	Karabağ S, Öznur M, Garip Bilen Y, Avcı O. FBXW7 mutation is associated with poor overall survival in metastatic colorectal carcinoma: A retrospective single-center next-generation sequencing cohort study. World J Gastrointest Oncol 2026; In press DOI: https://doi.org/10.4251/wjgo.125213
PDF	125213-in-press.pdf

Received	2026-07-03 08:21
Peer-Review Started	2026-07-03 08:22
First Decision by Editorial Office Director
Return for Revision	2026-08-10 09:16
Revised	2026-08-19 15:58
Publication Fee Transferred	2026-09-10 10:41
Second Decision by Editor	2026-11-05 03:30
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-11-05 07:45
Articles in Press	2026-11-05 07:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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