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Articles in Press
11/5/2026 7:45:34 AM | Browse: 4 | Download: 1
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Use of N-of-1 trials in liver diseases: A systematic review
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Khalid M AlNaamani, Siham AlSinani and Mohamed El-Kassas |
| Funding Agency and Grant Number |
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| Corresponding Author |
Khalid M AlNaamani, Department of Medicine, Division of Gastroenterology and Hepatology, The Medical City for Military and Security Services, Muscat, Oman, Muscat 111, Oman. noumani73@gmail.com |
| Key Words |
N-of-1 trial; Liver Disease; Crossover design; Single-patient trials; Individualized treatment |
| Core Tip |
Many rare, chronic, and stable liver diseases are difficult to investigate using conventional randomized controlled trials. N-of-1 trials are randomized, multiple-crossover trials designed to evaluate treatment effects in an individual patient. In this scoping review, we identified only two hepatology studies using this design: One evaluating thiamine in chronic hepatitis B and the other evaluating ursodeoxycholic acid in hepatic sarcoidosis. These findings highlight the underuse of N-of-1 trials as a potentially valuable approach for studying rare, chronic, and stable liver diseases. |
| Citation |
AlNaamani KM, AlSinani S, El-Kassas M. Use of N-of-1 trials in liver diseases: A systematic review. World J Hepatol 2026; In press
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| PDF |
125240-in-press.pdf
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Received |
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2026-07-02 07:08 |
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Peer-Review Started |
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2026-07-02 07:08 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-19 03:19 |
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Revised |
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2026-09-01 18:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-11-05 03:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-05 07:45 |
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Articles in Press |
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2026-11-05 07:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
