Publication Name	World Journal of Psychiatry
Manuscript ID	125255
DOI	10.5498/wjp.125255
Country	China

Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Relapse prediction after remission in major depressive disorder: From single classification to sequential clinical decisions
Manuscript Source	Invited Manuscript
All Author List	Si-Yi Chen, Yi-Fan Fang, Qing Du, Guo Li and Zhou Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82101605 and 82301505 National Center for Major Public Health Events 2026N2M06 Interdisciplinary Research Program of Huazhong University of Science and Technology 2024JCYJ004 Tongji Hospital Key Funding 2024A14 Wuhan Key Research and Development Program 2025020102030017
Corresponding Author	Zhou Zhu, MD, PhD, Professor, Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. zhouzhu@hust.edu.cn
Key Words	Major depressive disorder; Relapse prediction; Remission; Digital phenotyping; Machine learning; Clinical decision-making
Core Tip	Relapse prediction in remitted major depressive disorder has usually been framed as a single binary classification problem. This review argues that prevention instead requires a sequence of clinical decisions: Who needs closer follow-up, when behaviour deviates from a personal baseline, and whether that deviation warrants action. We organise current evidence into a proposed Stratify-Monitor-Confirm framework. Baseline data configure monitoring intensity; passive sensing, brief repeated self-report, or both detect within-person drift; and triggered assessment confirms clinical meaning. This staged structure clarifies why different data sources should be evaluated against different clinical questions.
Citation	Chen SY, Fang YF, Du Q, Li G, Zhu Z. Relapse prediction after remission in major depressive disorder: From single classification to sequential clinical decisions. World J Psychiatry 2026; In press DOI: https://doi.org/10.5498/wjp.125255
PDF	125255-in-press.pdf

Received	2026-07-02 05:53
Peer-Review Started	2026-07-02 05:54
First Decision by Editorial Office Director
Return for Revision	2026-08-17 08:13
Revised	2026-08-23 05:14
Publication Fee Transferred
Second Decision by Editor	2026-10-19 06:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-20 09:45
Articles in Press	2026-10-20 09:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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