Publication Name	World Journal of Psychiatry
Manuscript ID	125256
Country	India

Category	Psychiatry
Manuscript Type	Review
Article Title	Neuropsychiatric manifestations of prostate cancer and its treatment: Biological mechanisms and psycho-oncology perspectives
Manuscript Source	Invited Manuscript
All Author List	Shivani Bhave, Yash Darji and Akhilesh Prajapati
Funding Agency and Grant Number	Funding Agency Grant Number GSBTM, DST Government of Gujarat No. GSBTM/RSS/E-FILE/30/2024/0021/04306791
Corresponding Author	Akhilesh Prajapati, Associate Professor, PhD, Research Dean, Division of Biotechnology, School of Life Sciences, GSFC University, Vigyan Bhawan, Fertilizer Nagar, Vadodara 391750, Gujarāt, India. akhileshbiotech06@gmail.com
Key Words	Prostate cancer; Depression; Anxiety; Androgen deprivation therapy; Cognitive impairment; Neuroinflammation; Oxidative stress; Psycho-oncology
Core Tip	Prostate cancer and its treatment can produce substantial neuropsychiatric consequences that extend beyond conventional physical and oncological outcomes. The available evidence supports routine recognition of psychological distress and targeted evaluation of mood and cognitive symptoms in higher-risk patients. Mechanistic biomarkers, neuroimaging approaches and precision psycho-oncology strategies remain important areas for further prospective validation. This narrative review distinguishes direct prostate cancer evidence from indirect mechanistic context and emphasizes practical psycho-oncology assessment alongside research priorities in neuroimaging, biomarkers and longitudinal care. We further highlight neuroimaging approaches, global disparities in psycho-oncological care and emerging brain–tumor communication pathways.
Citation	Bhave S, Darji Y, Prajapati A. Neuropsychiatric manifestations of prostate cancer and its treatment: Biological mechanisms and psycho-oncology perspectives. World J Psychiatry 2026; In press

Received	2026-07-02 02:27
Peer-Review Started	2026-07-02 02:28
First Decision by Editorial Office Director
Return for Revision	2026-08-03 08:46
Revised	2026-08-13 15:34
Publication Fee Transferred
Second Decision by Editor	2026-10-08 07:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-10-08 08:15
Articles in Press	2026-10-08 08:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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