Publication Name	World Journal of Clinical Cases
Manuscript ID	125278
DOI	10.12998/wjcc.125278
Country	Japan

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Butterfly effect of oral frailty and sensory blurring: A complex systems framework for hip fracture vulnerability
Manuscript Source	Invited Manuscript
All Author List	Takahiko Nagamine
Funding Agency and Grant Number
Corresponding Author	Takahiko Nagamine, MD, PhD, Professor Emeritus, Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu 747-0066, Japan. tnagamine@outlook.com
Key Words	Butterfly effect; Complex systems science; Descending pain inhibitory system; Hip fracture; Oral frailty; Sensory blurring
Core Tip	We should stop thinking about hip fracture risk through a simple, straight line of just bone density and falls. Looking at the human body as a complex system, things like oral frailty and age-related nerve changes (descending pain inhibitory system dysfunction) are like tiny initial disturbances in a big, interconnected web. Through sensory blurring, bad nutrition, and muscle loss, these small issues feed into each other and grow larger over time. This is exactly like the “butterfly effect”, where a tiny change eventually causes a major storm — or in this case, a bad hip fracture. This new model shows why we need to focus on whole-body resilience instead of just single medical targets.
Citation	Nagamine T. Butterfly effect of oral frailty and sensory blurring: A complex systems framework for hip fracture vulnerability. World J Clin Cases 2026; In press DOI: https://doi.org/10.12998/wjcc.125278
PDF	125278-in-press.pdf

Received	2026-07-09 05:52
Peer-Review Started	2026-07-09 05:52
First Decision by Editorial Office Director
Return for Revision	2026-08-05 05:57
Revised	2026-08-05 09:34
Publication Fee Transferred
Second Decision by Editor	2026-09-04 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-04 10:24
Articles in Press	2026-09-04 10:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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