Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	125316
DOI	10.4292/wjgpt.125316
Country	Saudi Arabia

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Predictors of Helicobacter pylori eradication failure and differential regimen vulnerability: A real-world cohort study from Saudi Arabia
Manuscript Source	Unsolicited Manuscript
All Author List	Salem Homoud Alshammari, Mohammed Almadani, Mahdi Albogami, Saad K. Alshammari, Khalid Almutairi, Anas Alowaidi and Mohammed Zakari
Funding Agency and Grant Number
Corresponding Author	Salem Homoud Alshammari, Academic Fellow, Consultant, Gastroenterology, King Abdulaziz Medical City, Riyadh, Saudi Arabia, Riyadh 22321, Saudi Arabia. saljanfawi1@gmail.com
Key Words	Helicobacter pylori; Bismuth quadruple therapy; Non-bismuth quadruple therapy; Antibiotic resistance; Eradication therapy; Saudi Arabia
Core Tip	In this cohort, neither bismuth nor non-bismuth quadruple therapy achieved the eradication target of ≥ 90% and the factors most strongly associated with failure were prior treatment and prior penicillin exposure. One key finding is that these factors were differentially associated with failure in the two regimens: Non-bismuth therapy was considerably more sensitive to prior treatment than bismuth therapy. This differential should be regarded as a hypothesis for future studies rather than a treatment guideline, given the limitations of a retrospective cohort.
Citation	Alshammari SH, Almadani M, Albogami M, Alshammari SK, Almutairi K, Alowaidi A, Zakari M. Predictors of Helicobacter pylori eradication failure and differential regimen vulnerability: A real-world cohort study from Saudi Arabia. World J Gastrointest Pharmacol Ther 2026; In press DOI: https://doi.org/10.4292/wjgpt.125316
PDF	125316-in-press.pdf

Received	2026-07-03 08:21
Peer-Review Started	2026-07-03 08:22
First Decision by Editorial Office Director
Return for Revision	2026-07-21 03:33
Revised	2026-07-23 14:07
Publication Fee Transferred	2026-07-28 14:21
Second Decision by Editor	2026-09-11 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-09-11 09:27
Articles in Press	2026-09-11 09:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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