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Articles in Press
11/5/2026 7:53:07 AM | Browse: 6 | Download: 2
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Tanyu Tongzhi decoction regulates cholangiocyte-endothelial crosstalk to promote lipid reduction and liver function recovery for hyperlipidemic rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Yang, Wen-Jing Zong, Cheng-Ze Li, Xiang Li, Tong Lei and Hua-Min Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82374182 |
| CACMS Innovation Fund |
No. CI2026A00110 |
| Beijing High-level Innovative and Entrepreneurial Talents Support Program |
No. G202514021 |
| Fundamental Research Funds for the Central Public Welfare Research Institutes |
No. ZZ17-YQ-033 |
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| Corresponding Author |
Hua-Min Zhang, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Dongcheng District, Beijing 100700, China. hmzhang@icmm.ac.cn |
| Key Words |
Hyperlipidemic; Single-cell sequencing; Lipid metabolism; Network pharmacology; Traditional Chinese medicine |
| Core Tip |
Tanyu Tongzhi decoction exerts lipid-lowering and hepatoprotective effects in hyperlipidemic rats. Using single-cell sequencing and targeted lipid metabolomics, this work reveals that Tanyu Tongzhi decoction remodels crosstalk between liver cholangiocytes and endothelial cells, restrains inflammation and lipotoxic injury, and modulates fluid shear stress as well as complement-coagulation cascades. Liver-distributed active ingredients form stable complexes with interleukin-6 and tumor necrosis factor-alpha to achieve multi-target therapeutic efficacy. |
| Citation |
Yang Y, Zong WJ, Li CZ, Li X, Lei T, Zhang HM. Tanyu Tongzhi decoction regulates cholangiocyte-endothelial crosstalk to promote lipid reduction and liver function recovery for hyperlipidemic rats. World J Gastroenterol 2026; In press
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| PDF |
125318-in-press.pdf
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Received |
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2026-07-06 09:21 |
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Peer-Review Started |
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2026-07-06 09:21 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2026-08-07 02:35 |
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Revised |
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2026-08-18 00:10 |
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Publication Fee Transferred |
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2026-08-26 02:55 |
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Second Decision by Editor |
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2026-11-05 03:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-11-05 07:53 |
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Articles in Press |
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2026-11-05 07:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
